The membrane-bound transcription factor site-1 protease (MBTPS1
) (also known as serine protease 1: S1P), a serine protease involved in SREBF1 activation, was predicted to be activated in all treatments as expected although not always in the top 20 (Inoue et al.
They said that mutation in Mbtps1 gene might contribute to IBD in humans.
and former Research Associate Sophie Rutschmann showed how the gene Mbtps1 is linked to ulcerative colitis in mice.
The study revealed that crippling the protein product of the Mbtps1 gene makes mice prone to colitis.
Genes in the genomic vicinity are HSBP1, heat-shock factor-binding protein 1; MBTPS1
, membrane-bound transcription factor protease, site 1; MIR3182, microRNA 3182; MLYCD, malonyl-CoA decarboxylase; NECAB2, N-terminal EF-hand calcium binding protein 2; OSGIN1, oxidative stress-induced growth inhibitor 1; SLC38A8, solute carrier family 38 (amino acid transporter), member 8.