ADAM1baa10

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ADAM1baa10

A widely expressed member of the ADAMs family of proteins encoded by ADAM10 on chromosome 15q2|15q22.
Activity Controls proteolytic processing of Notch, mediates lateral inhibition in neurogenesis, cleaves pro-TNF-alpha, myelin basic protein, and type IV collagen. It is responsible for the proteolytic release of other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). ADAM 10 contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. ADAM 10 is inhibited by TIMP-1 and TIMP-3.
References in periodicals archive ?
According to the company, the MADM mobile anaesthesia delivery module is designed and manufactured at its ISO 13485-certified facility in Toronto, Ontario, Canada.
TOPSIS method for MADM under single-valued neutrosophic environment was applied by Biswas et al.
DEA has been considered as an effective tool to solve MADM problems without information on weights.
Air Force Academy Operations Research Capstone class has developed a computer-based tool to help PMs complete the MADM analysis, and Air Force Materiel Command is developing a standardized process to facilitate the overall Cost Capability Analysis.
Later, Hwang and Yoon (1981) reviewed the MADM methods (SAW, TOPSIS, ELECTRE, LINMAP).
Hybrid fuzzy MADM project-selection model for diversified construction companies, Canadian Journal of Civil Engineering 37(8): 1082-1093.
Section 2 presents the related work on MADM methods and assessment of indoor environment.
Therefore, the MADM under the linguistic context is an interesting research topic which has been receiving more and more attention in recent years [1-4].
Reference [1],[2],[3] studied MADM problems that attribute weight information is interval number, attribute value is crisp number from various angles.
The multiattribute decision model, or MADM, attempts to develop a general measure of utility, defined as the satisfaction of an individual's or set of individuals' preferences.
Looking at the Sample Calculation on the next page, here's how MADM works, as recounted in AMT's Cost justification text:
To construct a MADM, an analyst makes a list of factors important in judging an investment's outcome.