ADAM1baa10

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ADAM1baa10

A widely expressed member of the ADAMs family of proteins encoded by ADAM10 on chromosome 15q2|15q22.
Activity Controls proteolytic processing of Notch, mediates lateral inhibition in neurogenesis, cleaves pro-TNF-alpha, myelin basic protein, and type IV collagen. It is responsible for the proteolytic release of other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). ADAM 10 contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. ADAM 10 is inhibited by TIMP-1 and TIMP-3.
References in periodicals archive ?
Air Force Academy Operations Research Capstone class has developed a computer-based tool to help PMs complete the MADM analysis, and Air Force Materiel Command is developing a standardized process to facilitate the overall Cost Capability Analysis.
Later, Hwang and Yoon (1981) reviewed the MADM methods (SAW, TOPSIS, ELECTRE, LINMAP).
Hybrid fuzzy MADM project-selection model for diversified construction companies, Canadian Journal of Civil Engineering 37(8): 1082-1093.
Atsizvelgiant i tai, portfeliui optimizuoti turetu buti naudojamos ne daugiau kaip triju (geriausia dvieju) tikslu sistemos, o investuotojui svarbios charakteristikos MADM metodais galetu buti integruojamos i viena bendra iverti, kurio maksimizavimas/ minimizavimas ir butu vienu is portfelio optimizavimo tikslu.
MADM methods are successfully applied in a great number of areas, like: risk analysis (Zavadskas et al.
This paper considers the fuzzy MADM problems that the alternatives are [X.
Looking at the Sample Calculation on the next page, here's how MADM works, as recounted in AMT's Cost justification text:
To construct a MADM, an analyst makes a list of factors important in judging an investment's outcome.
Hadavi race [12] to identify the factors affecting the selection of stocks in Tehran Stock Exchange (limited to cement companies) pays using MADM approach.
In recent years, Research on the MADM problems with the intuitionistic fuzzy information has made a lot of achievements (Atanassov 1989; Liu 2009, 2013a, b, c; Liu, Jin 2012; Liu et al.