MAVARIC

MAVARIC

A randomised controlled trial that compared manual and automated (machine-read) screening of liquid-based cytology samples from the uterine cervix.

Outcome measure
The primary outcome measure (OM) was the sensitivity of automation-assisted reading relative to manual for the detection of CIN2+. A secondary OM was cost-effectiveness of each type of reading to detect CIN2+.

Results
Automated reading was 8% less sensitive than manual reading. “No further review” by automated reading was very reliable; if restricted to routine screening samples, <1% of CIN2+ would have been missed.

Conclusion
The much lower sensitivity of automated reading, combined with uncertainty over its cost-effectiveness, suggests that there is no justification to recommend its use. The reliability of the “no further review” diagnosis may be of value as a way of saving staff time.
References in periodicals archive ?
After the war ended, Arnold returned to Wales and his family drapery business, while von Mavaric went back to Germany.
A photograph showing Arnold and von Mavaric together, both men once again in military uniform the German clutching the Welshman's arm, offers a fascinating insight into the turn von Maravic's life took.