MAPK4

MAPK4

A gene on chromosome 18q21.2 that encodes a protein of the MAP kinase (MAPK) family. MAP kinases integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. Once MAPK4 is activated by phosphorylation by an upstream tyrosine kinase, it translocates to the nucleus of the stimulated cell, where it phosphorylates target molecular.
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Bartholomeu, "Linear B-cell epitope mapping of MAPK3 and MAPK4 from Leishmania braziliensis: implications for the serodiagnosis of human and canine leishmaniasis," Applied Microbiology and Biotechnology, vol.
Guo and his colleagues showed that the ectopic expression of miR-433 and miR-127 in gastric cancer cell lines inhibits cell proliferation, cell cycle progression, cell migration, and invasion by directly interacting with the mRNA encoding oncogenic factors KRas and MAPK4, respectively [19].
On the other hand, several genes involved in non-Smad signaling pathway were also up-regulated, such as MAPK4 and RAB8, which belong to Ras/GTPase family and are involved in the Ras/mitogen-activated protein kinase (MAPK) pathway.