MAPK3


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MAPK3

A gene on chromosome 16p11.2 that encodes a protein of the MAP kinase family. MAP kinases (e.g., extracellular signal-regulated kinases) integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. Once MAPK3 is activated by phosphorylation by an upstream kinase, it translocates to the nucleus of the stimulated cell, where it phosphorylates target molecules.
References in periodicals archive ?
Signaling pathways in response to salt stress in tomato include many signaling molecules such as mitogen-activated protein kinase 2 (MAPK2) and MAPK3 (Stulemeijer et al.
In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis.
The researchers found the virus activated two microRNAs that turned on the genes IRAK1 and MAPK3, and this resulted in a decrease in the amount of proteins that help turn on the immune response.
Several molecular targets were identified in the IL-6 pathway (CSNK2A1, MAPK3, IL6, JUN, STAT3, and FOS), but previous knockout studies failed to show that the IL-6 pathway was critical to rodent embryo development (Sakurai et al.