MAPK3


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MAPK3

A gene on chromosome 16p11.2 that encodes a protein of the MAP kinase family. MAP kinases (e.g., extracellular signal-regulated kinases) integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. Once MAPK3 is activated by phosphorylation by an upstream kinase, it translocates to the nucleus of the stimulated cell, where it phosphorylates target molecules.
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As a molecular mechanism of apelin action on the steroid synthesis process authors considered activation of the serine-threonine kinase, mitogen activated protein kinase (MAPK3) and AMPK kinase pathways [58].
Bartholomeu, "Linear B-cell epitope mapping of MAPK3 and MAPK4 from Leishmania braziliensis: implications for the serodiagnosis of human and canine leishmaniasis," Applied Microbiology and Biotechnology, vol.
These genes are BDNF (brain-derived neurotrophic factor), NTRK2 (neurotrophic tyrosine kinase type 2 receptor, also known as TrkB), SH2B2 (SH2B adaptor protein 2, also known as rAPS), MAPK3 (mitogen-activated protein kinase 3, also known as Erk), MAPK12 (mitogen-activated protein kinase 12, also known as p38), MAPKAPK2 (mitogen-activated protein kinase-activated protein kinase 2), and ATF4 (activating transcription factor 4, also known as CREB).
The expression levels of the five important genes for pathogenesis of SAD including Syp, Psenl, Mapk3, Map2 and Tnf-[alpha] were measured by qPCR between the hippocampi of SAD model which were treated by this herbal extract and control groups.
Signaling pathways in response to salt stress in tomato include many signaling molecules such as mitogen-activated protein kinase 2 (MAPK2) and MAPK3 (Stulemeijer et al., 2007).
In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis.
Different kinases and groups of kinases like CK2, PLK1, IKK, PKC, MAPK3, SIK, AMPK, INSR, and RSK1 were involved in phosphorylation of IRS-1 on same or different residues.
Meanwhile, MAPK signaling pathway molecules including MEKK1, ASK1 (MAP3K5), MLK2 (MAP3K10), MLK3, NIK, MEK1 (MAP2K1), MEK2 (MAP2K2), MEK4 (MAP2K4), MEK7 (MAP2K7), ERK1 (MAPK3), JNK1 (MAPK8) and JNK2 (MAPK9) were significantly up-regulated and revealed 2.00-4.09 fold increases in expression level (Table 1).
The researchers found the virus activated two microRNAs that turned on the genes IRAK1 and MAPK3, and this resulted in a decrease in the amount of proteins that help turn on the immune response.
The researchers found the virus activated two microRNAs that turned on the genes IRAK1 and MAPK3. This resulted in a decrease in the amount of proteins that help turn on the immune response.
Al mismo tiempo, la estimulacion de la renina activa los genes ERK1 (MAPK3) y ERK2 (MAPK1), que se relacionan con obesidad y con hipertrofia cardiaca, entre otras cosas (6,7).
The result showed that 11 overlapping proteins (ACACA, ampC, APP, BCL2, CDK2, FASN, gyrB, katA, KCNH2, MAPK3, and NR3C1) were related to many different biological functions including oxidoreductase activity, MAP kinase activity, and NF-kappa-B binding (Figure 11(a)).