MAPK1

(redirected from MAPK2)

MAPK1

A gene on chromosome 22q11.2|22q11.21 that encodes a protein of the MAP kinase family. MAP kinases (e.g., extracellular signal-regulated kinases) integrate multiple biochemical signals, and are involved in cell proliferation, differentiation, transcription, regulation and development. Once MAPK1 is activated by phosphorylation by an upstream kinase, it translocates to the nucleus of the stimulated cell, where it phosphorylates target molecules.
References in periodicals archive ?
Shanahan, "Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation," The Journal of Biological Chemistry, vol.
19p13.3 microdeletion/duplication syndrome has been previously described within the literature; however, the shortest region of overlap (SRO) is approximately 150 kb and includes one microRNA (SNORD37) and four genes (PIAS4, ZBTB7A, MAPK2, and partially EEF2).
This cascade of events involves mitogen-activated protein kinases (MAPK), MAPK1 (ERK1), MAPK2 (ERK2), and p38-MAPK [3, 142].
Of the examined salt stress genes, four genes, AREB, MAPK2, P5CS and CRK1, were up-regulated by AgNPs under salt stress, and three genes, TAS14, DDF2 and ZFHD1, were down-regulated in response to AgNPs.
Signaling pathways in response to salt stress in tomato include many signaling molecules such as mitogen-activated protein kinase 2 (MAPK2) and MAPK3 (Stulemeijer et al., 2007).
MAPK2 was also not expressed in non-treated control plants and had strong expression in tomato plants with both NaCl stresses and AgNP treatments.
Of the investigated salt stress genes in tomato plants, the AIM1, AGP-S1, APX2, LOX1 and MAPK2 genes were expressed only under NaCl stress, and they were not expressed in non-treated plants.
The expression of four genes: AREB, MAPK2, P5CS and CRK1, was up-regulated by AgNPs under both salt levels, NaCl150 and NaCl200.