MAPK13


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MAPK13

A gene on chromosome 6p21.31 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK13 is phosphorylated and activated by MAP kinases—especially MKK3 and MKK6; it is closely related to p38 MAP kinase and both are activated by pro-inflammatory cytokines and environmental stress, and in turn phosphorylate downstream targets.
References in periodicals archive ?
Increased MAPK13 gene expression is evident in the lungs of patients with severe COPD [83].
Interestingly, hypermethylation of the MAPK13 gene promoter region has recently been characterised in both malignant pleural mesothelioma [103] and primary cutaneous melanoma [104].
For MAPK13, that pocket itself has some obstructions that make it more crowded and harder to access, so these older drugs can't fit into the pocket to block activity."
The team worked around the problem by building drugs with slimmer structures that could avoid the obstacles and better fit into the protein pocket of MAPK13. "We sculpted the drugs so they're better able to bind in the MAPK13 pocket," Dr.
(33,34,44) It was recently suggested that DNA methylation at 3 specific loci, TMEM30B, KAZALD1, and MAPK13, could be useful in the differential diagnosis of MPM.