MAPK11

MAPK11

A gene on chromosome 22q13.33 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK11 is preferentially activated by MAPK kinase—especially MKK6; it is closely related to p38 MAP kinase and both are activated by pro-inflammatory cytokines and environmental stress.
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The phospholipase C beta 1 (PLCB1), PLCB4, adenylate cyclase 2 (ADCY2), ADCY8, calcium/calmodulin dependent protein kinase II beta (CAMK2B), CAMK2D, mitogen-activated protein kinase 11 (MAPK11), MAPK14, epidermal growth factor receptor (EGFR), growth factor receptor bound protein 2 (GRB2), Fyn proto-oncogene, Src family tyrosine kinase (FYN), and integrin subunit beta 5 (ITGB5) genes were involved in 12 significantly enriched pathways and accounted for 0.126% of the genetic variance for MY, 0.109% for FY, and 0.197% for AFC (Supplementary File SI).
The mammalian MAPK family consists of ERK, p38, and JNK with each member having several isoforms: ERK1 to ERK8; p38a (MAPK14), p38fi (MAPK11), p38g (MAPK12), and p38S (MAPK13); and JNK1 (MAPK8), JNK2 (MAPK9), and JNK3 (MAPK10).
The p38 MAPK family members (p38, MAPK11, SAPK3, and SAPK4) are activated by inflammatory cytokines, UV radiation, and external stress such as heat shock and high osmotic stress.
In fact it appears that MAPK12 (p38[gamma]) arose from a tandem duplication of MAPK11 (p38[beta]) on chromosome 22 while MAPK14 (p38[alpha]) and MAPK13 (p38[delta]) subsequently resulted from a single segmental duplication of the MAPK11-MAPK12 gene unit on chromosome 6 [11].
Eftychi et al., "Generation and characterization of p38[beta] (MAPK11) gene-targeted mice," Molecular and Cellular Biology, vol.
p38 family members are classified into four subtypes: a (MAPK14), (MAPK11), y (MAPK12/ERK6), and S (MAPK13/SAPK4) (Table 1).
In the MAPK pathway, there were 14 differentially expressed genes (P < 0.05): DUSP1, GNA12, RAC1, MRAS, ELK1, ATF4, MAPK3, CDC25B, STMN1, MAX, TGFBR2, MAPK11, CACNB3, FGF8, and RASA2 (Table 5).
In addition, differentially expressed genes involved mainly in molecular functions were mainly related to protein binding, Hsa04620: toll-like rece 8 0.45% RAC1, TRAF3, MAPK3, IFNAR1,0.00002 signaling pathway TICAM1, IL6, MAPK11, and IFNA1 nucleic acid binding, structure-specific DNA binding, RNA binding, and hexosaminidase activity.
In this study 14 MAPK signaling genes were differentially expressed, including GNA12, DUSP1, MAPK11, RAC1, MRAS, ELK1, ATF4, MAPK3, CDC25B, STMN1, MAX, TGFBR2, CACNB3, FGF8, and RASA2 (P < 0.01).
Our present study found that eight key genes from the TLR signaling pathway (including RAC1, TRAF3, MAPK3, IFNAR1, TICAM1, IL6, MAPK11, and IFNA1) were significantly differentially expressed (P < 0.01).