MAPK1


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MAPK1

A gene on chromosome 22q11.2|22q11.21 that encodes a protein of the MAP kinase family. MAP kinases (e.g., extracellular signal-regulated kinases) integrate multiple biochemical signals, and are involved in cell proliferation, differentiation, transcription, regulation and development. Once MAPK1 is activated by phosphorylation by an upstream kinase, it translocates to the nucleus of the stimulated cell, where it phosphorylates target molecules.
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We found that the 3' UTR segment of human MAPK1 gene contains a sequence that is complementary to nucleotides of hsa-miR-1229-5p (Figure 4A).
By using luciferase dual reporter assay, MAPK1 was identified as a new target of miR-1229-5p.
NANOG (restricted to ICM), SOX2 (restricted to ICM), CDH1, HAND1, and MAPK1 (functions on cell differentiation and TE development) were downregulated in the 5% [O.sub.2] group.
miR-28-5p target Tumor type Reference p21 Choriocarcinoma cells [15] MPL Myeloproliferative neoplasms [16] N4BP1 Myeloproliferative neoplasms/ [9] ovarian cancer OTUB1 Myeloproliferative neoplasms [16] TEX-261 Myeloproliferative neoplasms [16] MAPK1 Myeloproliferative neoplasms [16] E2F6 Myeloproliferative neoplasms [16] MAD2L1 B-cell lymphomas [5] BAG1 B-cell lymphomas [5] RAP1B B-cell lymphomas/renal cell [3, 5] carcinoma
The enriched functions for genes in two downregulated modules (d-1 and d-5) with higher enrichment scores showed that genes in module d-1 (e.g., MAPK1, MAPK14, MITF, RAF1, JAK1, HBEGF, ROS1, and STAT3) were related to cell surface receptor linked signal transduction (P=1.71E-03), and enzyme-linked receptor protein signaling pathway (P=2.02E-03); while genes in module d-5 (e.g., PIP5K1B, PIP5K1C, PIP4K2B, CXCL12, and FN1) were mainly enriched in phosphatidylinositol metabolic processes (P=4.24E-04), glycerolipid metabolic processes (P=1.88E-03), and cell morphogenesis (P=2.06E-02; Table 4).
Five pathways were enriched for genes in the module d-1 (MAPK1, MITF, RAF1, JAK1, and STAT3): pancreatic cancer (P=5.47E-04), melanoma (P=8.52E-03), melanogenesis (p=1.48E-02), acute myeloid leukemia (P=7.67E-03), and cancer pathways (P=3.69E-03).
Ortego-Centeno et al., "Altered AKT1 and MAPK1 gene expression on peripheral blood mononuclear cells and correlation with T-helper-transcription factors in systemic lupus erythematosus patients," Mediators of Inflammation, vol.
MafA levels in beta-cells might be regulated by posttranscriptional mechanisms, such as the phosphorylation of two residues (serines 14 and 65) located in the transcriptional activating domain by the mitogen-activated protein kinase 1 (also known as MAPK1 or ERK2).
However, all major downstream signaling pathways of EGFR, such as AKT serine/threonine kinase (AKT)--mechanistic target of rapamycin (mTOR) pathway [22], Janus kinase (JAK)--signal transducer and activator of transcription (STAT) pathway [23], or mitogen-activated protein kinase 1 (MAPK1) pathway [17], are reported to induce PD-L1 expression.
Through coexpression network construction and analysis of node degree, we found some functional and high connected hubs varied in EC and HIP region, such as CHRM1, MAPK1, TGFBR1, LIFR, ERBB4, ERBIN, ATP5C1, IGF1R, GJA1, TJP1, AP2M1, CDK5, FGF2, TUBB, SLC22A3, DBT, CDK13, NLN, and MIF.