mitogen-activated protein kinase

(redirected from MAPK cascade)

MAP kinase

Any of a family of serine/threonine protein kinases belonging to the CMGC (CDK/MAPK/GSK3/CLK) kinase group, which are involved in cellular responses to various stimuli (e.g., mitogens, osmotic stress, heat shock and cytokines) and regulate cell growth, cycling, differentiation, mitosis and apoptosis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

mitogen-activated protein kinase



A signaling protein, i.e., a protein that circulates extracellularly influencing other cells to turn on the process of protein synthesis. These proteins have an effect on cellular replication and cellular death in inflammatory, ischemic, and malignant diseases.

mitogen-activated protein kinase

Abbreviation: MAPK
A signaling enzyme, i.e., one that circulates extracellularly, influencing cells to begin protein manufacturing. They affect cellular replication and death in inflammatory, ischemic, and malignant diseases.
See also: protein kinase
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
However, levels of p p38 MAPK were significantly enhanced by GSTD treatment (P<0.05, P<0.01, Figure 4B and C), suggesting that the p p38 MAPK cascade was associated with HO-1 and Nrf2 expression.
Especially, bone morphogenetic protein (BMP)-binding endothelial cell precursor-derived regulator (BMPER), forkhead box protein O1 (FOXO1), ectodysplasin A receptor, ring finger protein 149 (RNF149), cluster of differentiation (CD40), tyrosine-protein phosphatase non-receptor type 1 (PTPN1), SRY (sex determining region Y)-box 9 (SOX9), MYC proto-oncogene (MYC), and macrophage migration inhibitory factor were categorized as genes related to both MAPK cascade and the regulation of MAPK cascade.
Simulation benchmarks comprehend two biological models (the MAPK cascade and the Gemcitabine mechanism of action) to test simulation strategies in real modeling applications plus two theoretical models (the fully connected model and the multiscale model) considered with two different parameterisations each, to evaluate the performance of simulation algorithms under specific conditions.
The oxidized target proteins activate a number of oxidation-sensitive processes that bring about a number of cellular responses, such as gene activation, modulation of ion channels, and the activity of other signaling pathways, including MAPK cascade. Among the MAP3K family, ASK1 (apoptosis signal-regulating kinase 1) has been extensively characterized as an ROS-responsive kinase, which possesses a serine/threonine kinase domain in the middle part of the molecule flanked by the N- and C-terminal coiled-coil (CCC) domains.
(4) The GTP-bound small GTPases subsequently activate the first kinase tier of the MAPK cascade by inducing an allosteric conformational change in the MAPKKKs.
A MAPK cascade consists of three classes of protein kinases: MAPK, MAPK kinase (MAPKK) and MAPK kinase kinase (MAPKKK).
Each MAPK cascade consists of three kinase modulates which include an MEK kinase (MEKK), a mitogen-activate protein kinase/extracellular signal regulated kinase (MEK), and a mitogen-activated protein kinase (MAPK) [15-18].
(2004) investigated the involvement of a mitogen-activated protein MAPK cascade in this process.
Blockade of the MAPK cascade with the MEK inhibitor PD98059 inhibited phosphorylation of ELK-1, activation of NF-[kappa]B, and gene expression of NR1, NR-2A, and NK-1R; and prevented the development of spontaneous pain behavior.
Thus, the salt-stress regulated MAPK cascade consisting of AtMEKK1, AtMEK1/AtMKK2, and AtMPK4 is negatively regulated by MKP1.
MAPK cascade transmits signals from outer cell surface to the nucleus and is involved in fungal survival mechanisms against environmental stress conditions (35).