MAP3K6A gene on chromosome 1p36.11 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K6 activates the JNK MAPK pathways in response to various signals, including calcium and GPCR signalling and endoplasmic reticulum stress, but does not activate ERK or P38 signalling pathways.
Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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