MAP3K5

MAP3K5

A gene on chromosome 6q22.33 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K5 activates the P38 and JNK MAPK pathways in response to various signals, including calcium and GPCR signalling and endoplasmic
reticulum stress. It is highly expressed in the heart and pancreas.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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Endochondral Actin Focal TGF[beta] MAPK ossification cytoskeleton adhesion signaling signaling FGF2 FGF1 ITGA6 UCHL5 STMN1 TGFB2 FGF2 STYK1 CDC2 DUSP1 PLAT FGF5 CAV1 SMURF2 TRAF2 CALM1 FGF22 CAV2 NEDD9 BDNF ADAMTS1 KRAS CAV3 STAMBPL1 MAP3K5 OPG NRAS LAMC2 CCNB2 ACVR1C C11orf13 THBS1 RBL1 KRAS F2R PXN MAPK8 TGFB2 CRK RHOB PARD6A NRAS PAK1 PDPK1 CAV1 PPP5C ARHGEF7 MYLK2 TFDP1 PAK1 VIL2 PAK1 KLF6 CRK PXN MAPK8 FST MAPK8 BCL2 SERPINE1 CCND3 THBS1 CRK NOG HRAS Table 3: Genes involved in adipogenesis-related pathways that are upregulated in CYD-treated hMSCs.
Some of hypomethylated loci were key genes in the pathogenesis of RA, including CHI3L1, CASP1, STAT3, MAP3K5, MEFV, and WISP3.
Also, MAP3K5, PEX7, and DSCAM gene were suggested as candidate genes of RFI traits based on the GWAS results of 1,272 pigs [29].
Genes namely ATP-binding cassette, sub-family A (ABC1), member 12 (ABCA12), fibronectin leucine rich transmembrane protein 2 (FLRT2), LIM homeobox 4 (LHX4), mitogen-activated protein kinase kinase kinase 5 (MAP3K5), nutritionally-regulated adipose and cardiac-enriched (NRAC), netrin G1 (NTNG1), phosphatidylinositol glycan anchor biosynthesis, class N (PIGN), and zinc finger protein 75a (ZNF75A) were identified to be associated with calf birth weight in Holstein cattle.
In addition, 24% of melanomas were found to exhibit MAP3K5 (MAP kinase kinase kinase 5; synonyms: ASK1, MEKK5) and MAP3K9 (MAP kinase kinase kinase 9; synonyms: MlK1, MEKK9) mutations.
Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing.
Meanwhile, MAPK signaling pathway molecules including MEKK1, ASK1 (MAP3K5), MLK2 (MAP3K10), MLK3, NIK, MEK1 (MAP2K1), MEK2 (MAP2K2), MEK4 (MAP2K4), MEK7 (MAP2K7), ERK1 (MAPK3), JNK1 (MAPK8) and JNK2 (MAPK9) were significantly up-regulated and revealed 2.00-4.09 fold increases in expression level (Table 1).
(57) Moreover, genetic allelic analysis of HD patients demonstrates that sequence variations of the MAP3K5 and MAP2K6 genes, which encode ASK1 and MKK6, respectively, appear to modify the age of onset of HD.
Term Count P value Genes MAPK signaling pathway 13 0.0062 RPS6KA5, AKT1, MAP4K4, MAP3K5, PLA2G4A, DUSP2, FGF9, TGFBR1, MAP2K4, MKNK2, PPP3R1, FGF12, DUSP6 Endocytosis 10 0.010 IGF1R, ADRB3, FLT1, TGFBR1, PSD3, VPS4B, DNAJC6, PSD2, ARAP2, LDLRAP1 Axon guidance 7 0.042 EPHA5, SEMA6A, PLXNA1, PPP3R1, SEMA4C, L1CAM, SRGAP1 Insulin signaling 6 0.0076 AKT1, L1CAM, IGF1R, IRS2, pathway SOCS7, RHOQ Focal adhesion 4 0.021 VCAM1, L1CAM, ITGA4, CERCAM Table 2: Small molecules which might reverse the dysregulation of AD in EC and HIP regions.