MAP3K2

MAP3K2

A gene on chromosome 2q14.3 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K2 regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7, and it plays a role in caveolae kiss-and-run dynamics. MAP3K2 also interacts with MAPK8, SH2D2A, STK38, and XIAP.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
Mentioned in ?
References in periodicals archive ?
Although the known targets of miR-186 have not been completely clarified, research has found that miR-186 targets mitogen-activated protein kinase kinase kinase 2 (MAP3K2) (23), protein phosphatase PPM1B (24), and Jagged1 (25) to regulate cancer cell proliferation and metastasis.
MicroRNA-186 suppresses cell proliferation and metastasis through targeting MAP3K2 in non-small cell lung cancer.
Some of the potential targets of miR-302b-3p identified in humans (TargetScanHuman 7.1) are MAP3K2, BCL6, CCND2, CCND1, FGF10, RADA2, SMAD2, PAK3, and TGFfiR2 [13].
Forward (F) and reverse (R) primers for MAP3K3 (XM_015299375, F: 5'-TGA CCC GGA AAT ACA CTC GC; R: 5'-ACA TTC CCA GCA GAG TCA CG), MAP3K2 (XM_015290042, F: 5'-TGA GGG ACC CAC CAG AAA GA; R: 5'-GCG AGT CAC GTT CTC TGT CA), AQP4 (NM_001004765, F: 5'-GTG CCA GTA TGA ACC CTG CT; R: 5'-AAG AGC ACC AGC AAG GAC TG), and IGF2BP3 (NM_001006359, F: 5'-GCC TTG GCA GTT GGA GCT AT; R: 5'-AGC TTG GCA TCT GGT CCT TC) were designed using the Primer3 program (National Center for Biotechnology Information [NCBI] database) and synthesized by Genotech Co.
The miRNA gga-miR-20b-5p targets 581 genes, with the top-ranking/ top-scoring gene being MAP3K2 (target rank 1, score 100).
Real-time qPCR was used to further examine the expression of the four miRNAs (gga-miR-9-5p, gga-miR-20b-5p, gga-miR196-5p, and gga-let-7d) that showed the highest fold-changes in the IML of NE-induced chickens, compared to their respective controls, as well as the expression of their top-ranking target genes (MAP3K3, MAP3K2, AQP4, and IGF2BP3, respectively) (Figure 2).
This hypothesis is somewhat supported in the case of gga-miR-9-5p, gga-miR-20b-5p, gga-miR-196-5p, and gga-let-7d and the expression of their target genes MAP3K3, MAP3K2, AQP4, and IGF2BP3, respectively in the IML of NE-induced M5.1 chickens.
Thorley-Lawson, "EBV microRNA BART 185p targets MAP3K2 to facilitate persistence in vivo by inhibiting viral replication in B cells," Proceedings of the National Academy of Sciences of the United States of America, vol.
Some of the target genes were closely related to cancer development, such as CDH2, ZEB2, MAP3K2, and SLC24A4.
EBV miRNA BART 18-5p targets MAP3K2 and promotes viral persistence in vivo by suppressing viral replication in latently infected B-cells [161].
Thorley-Lawson, "EBV microRNA BART 18-5p targets MAP3K2 to facilitate persistence in vivo by inhibiting viral replication in B cells," Proceedings of the National Academy of Sciences of the United States of America, vol.