MAP3K13


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MAP3K13

An oncogene on chromosome 3q27 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K13 activates the JUN N-terminal pathway by activating the MAP kinase kinase MAP2K7. It acts synergistically with PRDX3 to regulate kinase-dependent NF-kappaB activation in the cytosol, which involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappaB.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
References in periodicals archive ?
The top two CpG islands, found in the mitogen-activated protein kinase kinase kinase 13 (MAP3K13) and transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 (TPTE2) genes, were statistically significant after FDR correction.
For validation, methylation was analyzed by site-specific pyrosequencing at three sites: (1) the top differentially methylated CpG site in the overall discovery sample (CDH22) and (2) the top differentially methylated CpG islands for males (CCDC8) and (3) females (MAP3K13).
Three sites within the MAP3K13 gene at genomic locations Chr3:185000779, Chr3:185000774, and Chr3: 185000760 were associated with metabolic syndrome status in females after adjusting for age, race, smoking status, and antipsychotic type (p = 0.01,0.04, and 0.01, resp.).