MAP3K12

MAP3K12

An oncogene on chromosome 12q13 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K12 may activate the JNK/SAPK pathway; it is highly expressed in brain and kidney.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
References in periodicals archive ?
Another study found that miR-130a inhibits the JNK pathway by targeting MAP3K12, contributing to its antiapoptotic effect and the maintenance of EPC function [15].
Yang et al., "MicroRNA-130a targets MAP3K12 to modulate diabetic endothelial progenitor cell function," Cellular Physiology and Biochemistry, vol.
In diabetes patients, miR-130a inhibits the JNK pathway by targeting MAP3K12, contributing to its antiapoptotic effect and the maintenance of endothelial progenitor cell (EPC) function under high glucose conditions [16].