MAP3K12 | definition of MAP3K12 by Medical dictionary
MAP3K12 An oncogene on chromosome 12q13 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K12 may activate the JNK/SAPK pathway; it is highly expressed in brain and kidney.
Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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References in periodicals archive
Another study found that miR-130a inhibits the JNK pathway by targeting MAP3K12, contributing to its antiapoptotic effect and the maintenance of EPC function .
Yang et al., "MicroRNA-130a targets MAP3K12 to modulate diabetic endothelial progenitor cell function," Cellular Physiology and Biochemistry, vol.
In diabetes patients, miR-130a inhibits the JNK pathway by targeting MAP3K12
, contributing to its antiapoptotic effect and the maintenance of endothelial progenitor cell (EPC) function under high glucose conditions .