Signaling pathways in PDPK1, CDKN2B, MAP2K5, BRAF, MAP2K7
, et al.
Meanwhile, MAPK signaling pathway molecules including MEKK1, ASK1 (MAP3K5), MLK2 (MAP3K10), MLK3, NIK, MEK1 (MAP2K1), MEK2 (MAP2K2), MEK4 (MAP2K4), MEK7 (MAP2K7
), ERK1 (MAPK3), JNK1 (MAPK8) and JNK2 (MAPK9) were significantly up-regulated and revealed 2.00-4.09 fold increases in expression level (Table 1).
Specifically, BCL2-antagonist/killer 1 (BAK1; catalog Number QT00228508), caspase 2, apoptosis-related cysteine peptidase (CASP2; QT01342509), integrin, beta 8 (ITGB8; QT00038507), mitogen-activated protein kinase kinase 7 (MAP2K7; QT00090545), myeloid cell leukemia sequence 1 (BCL2-related) (MCL1; QT00094122), and the rapamycin-insensitive companion of mTOR (RICTOR; QT00065793) were evaluated for potential changes in gene expression levels induced by formaldehyde exposure.
To further test this finding, we evaluated the gene expression levels of all four apoptosis signaling-related genes predicted to be targeted by miR-125b, namely BAK1, CASP2, MAP2K7, and MCL1.
As shown in Table 3, IRF1 and ZNRD1 are coexpressed with 356 (FASLG; Fas ligand) and 5609 (MAP2K7
; mitogen-activated protein kinase 7) in the influenza A pathways.
AKT1 CTNNB1 FGFR1 GNAS KRAS NRAS PIK3R5 STAT1 AKT2 EGFR FGFR2 HRAS MAP2K1 NTRK1 PKHD1 TEC AKT3 ERBB2 FGFR3 IDH1 MAP2K2 NTRK2 PRKCB1 TP53 (HER2) ALK ERCC6 FGFR4 IDH2 MAP2K7
NTRK3 RAF1 BRAF FBX4 FOXL2 IGF1R MET PDGFRA RET CDK4 FBXW7 GNA11 KDR MYC PIK3R1 SMO CSF1R FES GNAQ KIT NEK9 PIK3R4 SOS1