MAP2K7

A gene on chromosome 19p13.3-p13.2 that encodes a dual-specificity protein kinase that is as an essential component of the MAP kinase signal transduction pathway. With MAP2K4/MKK4, it is the only known kinase to directly activate the SAP/JNKs MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K7 has a specific role in the JNK signal transduction pathway activated by proinflammatory cytokines.

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18 MAP2K7 mitogen-activated protein kinase kinase 7 -0.

To further test this finding, we evaluated the gene expression levels of all four apoptosis signaling-related genes predicted to be targeted by miR-125b, namely BAK1, CASP2, MAP2K7, and MCL1.

It is important to note that these results do not demonstrate that miR-125b directly decreases the expression of BAK1, CASP2, MAP2K7, and MCL1 upon exposure to formaldehyde, nor that miR-142-3p directly increases the expression of ITGB8.

Formaldehyde and epigenetic alterations: microRNA changes in the nasal epithelium of nonhuman primates

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