MAP2K6

MAP2K6

A gene on chromosome 17q24.3 that encodes a dual-specificity protein kinase that is an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, MAP2K6 catalyses the phosphorylation of threonine and tyrosine residues in the MAP kinases MAPK11, MAPK12, MAPK13 and MAPK14, and it plays a key role in cellular responses to cytokines and cellular stress. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress; MAP2K6/MKK6 mediates apoptotic cell death in thymocytes, regulates melanocyte dendricity by modulating modulation Rho family GTPases, and is the major MAPK11 activator in response to TNF.
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These genes are: suppressor of glucose by autophagy (SOGA1), GLI family zinc finger 2 (GLI2), neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 (NYAP2), zinc finger protein multitype 2 (ZFPM2), rho GTPASE activating protein 24 (ARHGAP24), R-Spondin 2 (RSPO2), mitogen activated protein kinase kinase (MAP2K6), phospholipase C beta 1 (PLCB1), and cytoplasmic polyadenylation element binding protein 4 (CPEB4).
Pathway analysis shows that candidate genes PLCB1 and MAP2K6 genes participate in the gonadotropin signaling pathway (GnRH) (Figure 3).
GnRH signaling pathway containing PLCB1 and MAP2K6. GnRH, gonadotropin-releasing hormone; PLCB1, phospholipase C beta 1; MAP2K6, mitogen activated protein kinase kinas.
At the same time, the expression of seven genes (APC, CCNA1, FASLG, FOS, GJA1, MAP2K6, and MID1) showed more than a 2-fold change.
In combination with the information of mRNAs, IncRNA ENST00000585537.1 was found to be located on chromosome 17 and three protein-coding genes (MAP2K6, TEKT1, and ABCA5) were near its 300 kb area.
In the present study, we selected the following genes, sclerostin (Sost), low density lipoprotein receptor-related protein 6 (Lrp6), transcription factor 7-like 2 (Tcf7l2), alkaline phosphatase (Alpl), Mitogen-activated protein kinase kinase 6 (Map2k6) and nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 (Nfatc4) involved in the significant signaling pathway "role of osteoblasts, osteoclasts, and chondrocytes in rheumatoid arthritis" (Figure 4) for additional evaluation.
To confirm the differential gene expression detected by the microarray analysis and pathway analysis, we sampled six genes (Sost, Lrp6, Tcf7l2, Alpl, Map2k6, and Nfatc4) involved in the significant signaling pathway "role of osteoblasts, osteoclasts, and chondrocytes in rheumatoid arthritis" for verification using real-time PCR.
MAP2K6 is a direct and specific activator of all p38 MAPK isoforms identified to date [38].
We found that expressions of Map2k6 and Nfatc4 in the femur were all downregulated after treatment with RDE (Figure 5(a)).
(57) Moreover, genetic allelic analysis of HD patients demonstrates that sequence variations of the MAP3K5 and MAP2K6 genes, which encode ASK1 and MKK6, respectively, appear to modify the age of onset of HD.
(2008) ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease.
The genomic sequence variants identified for association with growth or growth-related traits of Korean cattle might include intragenic SNPs of the genes encoding dishevelled segment polarity protein 1 for eye muscle area (Kim et al., 2011), mitogen-activated protein kinase kinase 6 (MAP2K6) and uncoupling protein 2 for carcass weight (Ryu et al., 2012), and phosphodiesterase 1B (PDE1B) for Longissimus dorsi muscle area (Shin et al., 2012) and intergenic SNPs of rs110228023 for eye muscle area (Kim et al., 2011) and rs29012331 for yearling weight (Kim et al., 2014).