MAP2K6

MAP2K6

A gene on chromosome 17q24.3 that encodes a dual-specificity protein kinase that is an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, MAP2K6 catalyses the phosphorylation of threonine and tyrosine residues in the MAP kinases MAPK11, MAPK12, MAPK13 and MAPK14, and it plays a key role in cellular responses to cytokines and cellular stress. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress; MAP2K6/MKK6 mediates apoptotic cell death in thymocytes, regulates melanocyte dendricity by modulating modulation Rho family GTPases, and is the major MAPK11 activator in response to TNF.
References in periodicals archive ?
Pathway analysis shows that candidate genes PLCB1 and MAP2K6 genes participate in the gonadotropin signaling pathway (GnRH) (Figure 3).
GnRH signaling pathway containing PLCB1 and MAP2K6.
57) Moreover, genetic allelic analysis of HD patients demonstrates that sequence variations of the MAP3K5 and MAP2K6 genes, which encode ASK1 and MKK6, respectively, appear to modify the age of onset of HD.