Moreover, some genes and genetic loci were associated with restless legs syndrome (RLS) as follows: MEIS1 , BTBD9 , PTPRD , MAP2K5
/ SKOR1 , TOX3 , and RLS1-8 .
ORE Genes containing ORE up to 1000 bp upstream of the gene MNRR1 LOC105370119, MIR661, MNRR1, ST18, MADCAM1, (5-TGTCCCACGTCCGGA-3) RBBP8NL COX4I2 ADPRHL1, ADRA2A, C18orf8, C2CD2, CASZ1, CDH4, (5-TTCCCACGCTGGGG-3) CNPY4, COX4I2, EEF1DP3, ESYT1, FBP1, KIAA1614, LACTB, LINC00403, MAP2K5
, MARCKSL1, MIR36481, NOL9, RNF150, SDHAF1, USP28, WWC1
Regarding G2 versus G1, which evaluated the influence of the glycemic control in patients with T2D, the genes AGBL5 (p = 0043), CCDN3 (p = 00003), CEBPD (p <00001), VAMP2 (p = 00001), ENO2 (p <00001), and MAP2K5
(p = 0027) were significantly upregulated in the G2 subjects compared to the G1 subjects (Figure 1(b)).
Insulin signaling MAPK8, MAP2K5
, MINK1, RAF1, RAC1, et al.
A genome-wide association study in 922 cases with over 1,500 controls, all of European descent, found six loci, which identified RLS susceptibility: MEIS1, BTBD9, PTPRD, a locus encompassing MAP2K5
, and SKOR1 as well as a region on chromosomes 2p14 and 16q12.1 (Winkelmann et ah, 2011).
The annotated genes MAP2K5
and LBXCOR1 are located in the third locus, but because of the association study design the team could not differentiate which gene is ultimately involved in RLS.