MAP2K3

MAP2K3

A gene on chromosome 17q11.2 that encodes a MAPK kinase belonging to a protein kinase signal transduction cascade. MAP2K3 is a dual-specificity kinase, which is activated by cytokines and environmental stress; it catalyses phosphorylation of threonine and tyrosine residues in MAPK14/MAP kinase p38.

Molecular pathology
Defects in MAP2K3 have been described in colorectal cancer.
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Except for il-1a, MAP2k3, and TLR genes, we observed only modest effect of n-3 diet in inflammatory gene expression.
reported that elevated plasma miR-21 stimulated cell migration and invasion by targeting PTEN (phosphatase and tensin enzyme; part of a chemical pathway that inhibits cell division and triggers apoptosis) and PDCD4 (programmed cell death 4; a tumor suppressor gene) and it could also directly target MAP2K3 (mitogen-activated protein kinase 3) [31].
The expressions of Fos gene, Jun oncogene, and Map2k3 gene, which are related to MAPK pathways, were also regulated by KA and UR.
Another marker in this region is MAP2K3. MAP2K3 is a MAP kinase kinase family member that could potentially function as an oncogene by phosphorylating and activating p38 MAPK and MAPK14.
Gene ontology: biological Genes p-Value process terms Cell cycle CCNB1, CCNB2, MNAT1, CDC2, 2.7 E-14 CDKN 1 A, CDKN3, CDKN2A, ANAPC1, CDK10 Cellular metabolism KRT15, KIF1B, ZNF697, 4.3E-13 PRG2, P2RY2,IMMP2L Growth factor and growth BMP-2, TCF[beta]1, VEGF, 1.2E-11 factor receptor activity BMP8B, CSF1, FCFR1, BMPR2, 1GF2R, PDCFB, TGFBR2, NRP1, CCR2 Biosynthetic process CEL, COL11A2, ACPP, MMP14, 1.8E-9 CACNB1, ALPL, CDH1, ITGA3, SERPINB10, TAF4B, ABCB10, IRF8 Cell proliferation ATF3, MK167, S100A6, FTH1, DHCR7 2.1E-8 Signal transduction MAP2K3, MAPK14, MAP3K10, BAMBI, NDRG2, ECM1, SMAD7 5.5E-7 Apoptosis MYC, P53AIP1, ZBTB16, BBC3, 1.3E-5 VHL, CASP3, APITD1 Table 5 KEGG pathway analysis.