MAP2B | definition of MAP2B by Medical dictionary
MAP2 (redirected from MAP2B)
MAP2 A gene on chromosome 2q34 that encodes a protein belonging to the microtubule-associated protein family, which are involved in microtubule assembly, an essential step in neurogenesis. Based on similar genes in rodents, in humans the MAP2 protein product may play a role in determining and stabilising dentritic shape during neuronal development.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
At 5-6 days in vitro (DIV), cultures were transfected with plasmid-encoding microtubule-associated-protein-2B (MAP2B
) fused to enhanced green fluorescent protein (EGFP), which selectively labels the somata-dendritic domain (Wayman et al.
MAP2 isolated from rat brain consists of two major polypeptides (MAP2a and MAP2b
) of similar molecular weights, approximately 275 kD, although proteolysis can result in a 35 kD domain and a major 240 kD domain (Vallee, 1980).
To visualize dendritic arbors, cultures were transfected at 6 days in vitro (DIV) with the plasmid-encoding microtubule-associated-protein-2B MAP2B
(which labels the somatodendritic domain) fused to enhanced green fluorescent protein (EGFP) using Lipofectamine-2000 (Invitrogen) according to the manufacturer's protocol.