MAP2

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MAP2

A gene on chromosome 2q34 that encodes a protein belonging to the microtubule-associated protein family, which are involved in microtubule assembly, an essential step in neurogenesis. Based on similar genes in rodents, in humans the MAP2 protein product may play a role in determining and stabilising dentritic shape during neuronal development.

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microtubule-associated proteins

References in periodicals archive ?

To confirm the differentiation of DPSCs to a neuronal phenotype and to demonstrate that this differentiation was not an artefact, three analyses were performed: morphological changes, expression of MAP2, and activation of neuronal markers.

Differentiation of dental pulp stem cells into neuron-like cells in serum-free medium

EPA also caused NeuroD and Map2 mRNA levels to increase in Tuj-1-positive cells.

Omega-3 polyunsaturated fatty acids enhance neuronal differentiation in cultured rat neural stem cells

Representative immunofluorescent photographs of astrocyte markers GFAP and MAP2. Hoechst 33258 used as nuclei staining.

Irisin Exerts Neuroprotective Effects on Cultured Neurons by Regulating Astrocytes

QRT-PCR Analysis of MAP2, NF-[kappa]B, and NeuN Expression.

Combined Rosiglitazone and Forskolin Have Neuroprotective Effects in SD Rats after Spinal Cord Injury

Recently, the electromagnetic waves have been demonstrated to modulate the functions of the cytoskeleton and to promote the neuronal differentiation and the neurogenesis in the hippocampus in vivo through the upregulation of the Cav-1 channel, [beta]-III-tubulin, MAP2, and the brain-derived neurotrophic factor (BDNF) [29].

Low-Frequency Pulsed Electromagnetic Field Is Able to Modulate miRNAs in an Experimental Cell Model of Alzheimer's Disease

In pre-SCI rats, the (350 mg/kg/day) RGE-treated and vehicle-treated groups showed similar patterns of MAP2 immunoreactivity in the spinal cord (Figures 3(a) and 3(b)).

Oral Administration of Red Ginseng Extract Promotes Neurorestoration after Compressive Spinal Cord Injury in Rats

The membranes were blocked by emersion in 5% skim milk on a shaker at room temperature for 1h and then incubated overnight with primary antibodies against GAPDH, [beta]-tubulin III, MAP2, GFAP, tau, pSer9-GSK-3[beta] (Cell Signaling Technology), and [beta]-catenin.

Andrographolide Promotes Neural Differentiation of Rat Adipose Tissue-Derived Stromal Cells through Wnt/[beta]-Catenin Signaling Pathway

For quantitative assessment of cell differentiation in control and Paroxetine treated cells, the relative numbers of cells expressing different markers like mature neurons (MAP2), astrocytes (GFAP), and precursor neuronal cells (Nestin) were counted as percentages of the total DAPI-stained cell population.

Paroxetine can enhance neurogenesis during neurogenic differentiation of human adipose-derived stem cells

MAP2 was detected 72 h after the treatment under immunofluorescence microscope (Olympus, Japan) at 20x objective as described previously (Gaikwad and Agrawal-Rajput, 2015) using specific mouse monoclonal anti-MAP2 (1:1000) and Secondary antibody (goat anti-mouse IgG/IgM Alexaflour 488/543 (1:5000) (Invitrogen).

Berberine induces neuronal differentiation through inhibition of cancer stemness and epithelial-mesenchymal transition in neuroblastoma cells

Axonal and tissue preservation by immunohistochemistry (i.e., NeuN counts or fluorogold tract tracing), protein quantification (i.e., NF200, MAP2, CNPase western blot analysis), and cavity formation/tissue preservation imaging (i.e., luxol fast blue-hematoxylin eosin stain) are recommended.

Effect of aspirin on spinal cord injury: an experimental study

The two phases Map2 and Reduce2 take the result of the previous two phases as input in order to count the numbery [[beta].sub.i] of occurrences of each [x.sub.i].

Improve Data Quality by Processing Null Values and Semantic Dependencies

(91,92) Considering that among the proteins phosphorylated by PKA are the CREB transcription factor, (93,94) which stimulates BDNF expression and of its TrkB (49) receptor and MAP2 protein which stimulates the depolymerization of microtubules, (89,92) it is proposed that part of the therapeutic effect is due to the stimulation of the aforementioned cellular and synaptic plasticity processes.