MAP1B


Also found in: Acronyms.

MAP1B

A gene on chromosome 5q13 that encodes a protein belonging to the microtubule-associated protein family, which are involved in microtubule assembly, an essential step in neurogenesis. The MAP1B protein product is a precursor polypeptide, which is thought to undergo proteolytic processing to yield a MAP1B heavy chain and LC1 light chain. Mouse knockout studies suggest a role in development and function of the nervous system.
References in periodicals archive ?
Two known examples are neurofilament light chain (Nefl) [71] and microtubule-associated protein 1b (Map1b), the latter of which is the homologue of Drosophila Futsch [75, 76].
Recent work from the Shen group provides evidence that TDP-43 and FMRP coregulate dendritic translation of ~160 common targets, including Rac1, GluA1, and Map1b [84].
GluN3A also interacts with MAP1B [66] and MAP1-s [67].
Bjorklund et al., "MAP1B binds to the NMDA receptor subunit NR3A and affects NR3A protein concentrations," Neuroscience Letters, vol.