MAP1A

MAP1A

A gene on chromosome 15q15.3 that encodes a protein belonging to the microtubule-associated protein family, which are involved in microtubule assembly, an essential step in neurogenesis. The MAP1A protein product is a precursor polypeptide, which is thought to undergo proteolytic processing to yield a MAP1A heavy chain and LC2 light chain. Expressed almost exclusively in the brain, rat studies suggest a role in early spinal cord development.
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Microtubule-associated proteins (MAPs) have many subtypes, including MAP1A, MAP1B, MAP2, MAP4, and tau proteins.
Hyperphosphorylated tau sequesters normal tau and other neuronal microtubule associated proteins (MAPs), such as MAP1A, MAP1B, and MAP2, contributing further to disassembled microtubules, disruption of the axonal cytoskeleton, and transport, culminating as damaged neurons [52].