mitogen-activated protein kinase

(redirected from MAP kinases)

MAP kinase

Any of a family of serine/threonine protein kinases belonging to the CMGC (CDK/MAPK/GSK3/CLK) kinase group, which are involved in cellular responses to various stimuli (e.g., mitogens, osmotic stress, heat shock and cytokines) and regulate cell growth, cycling, differentiation, mitosis and apoptosis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

mitogen-activated protein kinase

,

MAPK

A signaling protein, i.e., a protein that circulates extracellularly influencing other cells to turn on the process of protein synthesis. These proteins have an effect on cellular replication and cellular death in inflammatory, ischemic, and malignant diseases.

mitogen-activated protein kinase

Abbreviation: MAPK
A signaling enzyme, i.e., one that circulates extracellularly, influencing cells to begin protein manufacturing. They affect cellular replication and death in inflammatory, ischemic, and malignant diseases.
See also: protein kinase
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
According to the same study, apocynin inhibited the expression of iNOS and COX-2, reduced NF-a, and inhibited the phosphorylation of MAP kinases JNK, ERK and P38.
We have systematically examined the role of MAP kinases and glucocorticoids in TNF-[alpha]-mediated CD38 expression in human cells.
Roskoski, "ERK1/2 MAP kinases: structure, function, and regulation," Pharmacological Research, vol.
Pae, "Reactive oxygen species in the activation of MAP kinases," Methods in Enzymology, vol.
We therefore investigated the effects of Hsp60 on the activation of the MAP kinases ERK1/2, JNK, and p38 and of the transcription factor NF[kappa]B which are preferentially activated by stress signals but are also essential for the coordination of adipocyte differentiation [44-46].
Han, "The primary structure of p38[gamma]: a new member of p38 group of MAP kinases," Biochemical and Biophysical Research Communications, vol.
For example, mitogen-activated protein kinases (MAP kinases) phosphorylate the N-terminal AF-1 domain of PPAR[gamma] (serine 84 or 112 in human PPAR[gamma]1 or PPAR[gamma]2, resp.), and this PTM inhibits ligand-dependent PPAR[gamma] transcriptional activity [7-11].
Flavell, "MAP kinases in the immune response," Annual Review of Immunology, vol.
In addition, GLT suppressed the activity of MAP kinases as observed by the down-regulation of LPS-induced phosphorylation of ERK1/2 and JNK but not p38.