MAP kinase

MAP kinase

Any of a family of serine/threonine protein kinases belonging to the CMGC (CDK/MAPK/GSK3/CLK) kinase group, which are involved in cellular responses to various stimuli (e.g., mitogens, osmotic stress, heat shock and cytokines) and regulate cell growth, cycling, differentiation, mitosis and apoptosis.
References in periodicals archive ?
Neflamapimod is a brain-penetrant oral small molecule that inhibits the intra-cellular enzyme p38 MAP kinase alpha.
2,3) RET/PTC rearrangement is a common activator of the MAP kinase pathway associated with thyroid malignancies.
UK-based Mereo BioPharma Group has reported positive results for its Phase one drug interaction study with acumapimod, the active compound in its p38 MAP kinase inhibitor, BCT-197, it was reported on Friday.
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells.
Role of Smad2/3 and p38 MAP kinase in TGF-[sz]1-induced epithelial-mesenchymal transition of pulmonary epithelial cells.
Combination therapy to inhibit the MAP kinase pathway is associated with a median overall survival of more than 2 years for patients with metastatic melanoma positive for the BRAF V600 mutation who have not previously received a BRAF inhibitor.
The mitogen-activated protein kinase (MAPK) cascades, consisting of the extracellular signal-related kinases (ERK1/2), the c-Jun N-terminal kinases (JNK), the p38 kinase (p38), and the big MAP kinase 1 (BMK1/ERK5) pathway [47], are major intracellular signal transduction pathways that play an important role in various cellular processes such as cell growth, differentiation, development, cell cycle, survival, and cell death [48].
grisea, well conserved biochemical signaling pathways are known including the cAMP signaling, PMK1 and MPS1 MAP kinase pathways (35,19,36,16) as well as carbohydrate mobilization and metabolism 42.
2005) Preheating Accelerates Mitogen-activated Protein (MAP) Kinase Inactivation Post-heat Shock via a Heat Shock Protein 70-mediated Increase in Phosphorylated MAP Kinase Phosphatase-1.
Since the MAP kinase family is known to be important in the regulation of cell growth, differentiation, and apoptosis (Davis 2000; Masuda et al.
MAP kinase cascades regulating axon regeneration in C.
1999) New insights into the control of MAP kinase pathways.