MAP3K3

MAP3K3

A gene on chromosome 17q23.3 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K3 activates NF-kappaB, AP1 and DDIT3 transcription regulators.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.