Based on drug class, the market has been further segmented into Levodopa combination, dopamine agonists, MAO-B Inhibitors
, COMT Inhibitors, and others.
Research shows that both dopamine agonists and MAO-B inhibitors are less effective than carbidopa/levodopa at quelling the motor symptoms associated with PD.
Thus, considering dopamine agonists and MAO-B inhibitors as initial therapy in patients ages <60 years may be helpful, since they typically will be taking medication longer.
Kupeli et al., "A new therapeutic approach in Alzheimer disease: Some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics," Bioorganic and Medicinal Chemistry, vol.
Bolasco, "Selective MAO-B inhibitors: A lesson from natural products," Molecular Diversity, vol.
Results show that the tested substances are powerful selective MAO-B inhibitors
, yet with the reversible type of inhibition typical of natural substances and plausibly devoid of any significant side effects.
A number of MAO-B inhibitors
used in the clinical setting for treating Parkinson's disease have unwanted side effects.
thus help improve the symptomatic motor effects of PD.
Agents such as the dopamine agonists, COMT inhibitors and MAO-B inhibitors
can assist in addressing these.
Depression in patients with dementia can be treated with selected tricyclics, MAO-B inhibitors
, and selective serotonin reuptake inhibitor medications.
: Minimally effective with troubling side effects
Da Prada M, Kettler R, Keller HH, Cesura AM, Richards JG, Saura Marti J, Muggli-Maniglio D, Wyss PC, Kyburz E, Imhof R (1990) From moclobemide to Ro 19-6327 and Ro 41-1049: the development of a new class of reversible, selective MAO-A and MAO-B inhibitors
. J Neural Transm 29: 279-292