The binding affinities of compound 6 with MAO-A and MAO-B were compared with reference MAO inhibitors
To summarize, resveratrol, quercetin, pterostilbene, and caffeic acid actually impaired the detection of the produced hydrogen peroxide without preventing benzylamine degradation and behaved as MAO inhibitors
and SSAO inhibitors only in appearance, as schematized in Figure 7.
The first generation of MAO inhibitors
(non-selective and irreversible) was characterized by a lack of selectivity in their MAO inhibition, inhibiting both MAO-A and MAO-B with serious side-effects (Cooper, 1989).
A few irreversible or non-selective MAO inhibitors
(e.g., phenelzine, tranylcypromine) are associated strongly with instances of severe serotonin syndrome, but a large number of opiates, analgesics, tricyclic antidepressants, selective serotonin reuptake inhibitors and antimigraine agents have also been implicated.
in depression resistant to cyclic antidepressants: two controlled crossover studies with tranylcypromine versus L-5-hydroxytryptophan and nomifensine.
Prescription medications that are most susceptible to interaction include the anti-clotting drug warfarin (Coumadin), some heart medications, and antidepressants called MAO inhibitors
, according to Dr.
Prior to the advent of SSRIs, physicians were reluc tant to even identify depression because the available treatments (MAO inhibitors
and, later, tricyclics) carried so many se rious side effects," said Dr.
The MAO Inhibitors
have an additional side effect of an adverse reaction with tyramine.
The mixture contains harmine, harmaline, and tetrahydroharmine, alkaloids that are also MAO inhibitors
. Participants prepare by eliminating fats, alcohol, and sugars, while increasing their consumption of seroton in-rich foods (such as bananas and fish), because this diet enhances the hallucinogenic effects of these MAO inhibitors
have many dietary restrictions, and people using these drugs need to follow the dietary guidelines and physician's instructions very carefully.
Caution should be exercised if BiDil is used with MAO inhibitors
, alcohol, sildenafil, vardenafil or tadalafil.