MAO inhibitor


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Related to MAO inhibitor: Ritalin, SSRI, serotonin, COMT inhibitor, MAOI inhibitor

inhibitor

 [in-hib´ĭ-tor]
1. any substance that interferes with a chemical reaction, growth, or other biologic activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.
ACE i's (angiotensin-converting enzyme i's) see angiotensin-converting enzyme inhibitors.
angiogenesis inhibitor a group of drugs that prevent growth of new blood vessels into a solid tumor.
aromatase i's a class of drugs that inhibit aromatase activity and thus block production of estrogens; used to treat breast cancer and endometriosis.
C1 inhibitor (C1 INH) a member of the serpin group, an inhibitor of C1, the initial component activated in the classical complement pathway. Deficiency of or defect in the protein causes hereditary angioedema.
carbonic anhydrase inhibitor an agent that inhibits the enzyme carbonic anhydrase; used in treatment of glaucoma and sometimes for epilepsy, familial periodic paralysis, acute mountain sickness, and kidney stones of uric acid.
cholinesterase inhibitor anticholinesterase.
COX-2 i's (cyclooxygenase-2 i's) a group of nonsteroidal antiinflammatory drugs that act by inhibiting cyclooxygenase-2 activity; they have fewer gastrointestinal side effects than other NSAIDs. Two members of the group are celecoxib and rofecoxib.
gastric acid pump inhibitor an agent that inhibits gastric acid secretion by blocking the action of H+,K+-ATPase at the secretory surface of gastric parietal cells; called also proton pump i.
HIV protease inhibitor any of a group of antiretroviral drugs active against the human immunodeficiency virus; they prevent protease-mediated cleavage of viral polyproteins, causing production of immature viral particles that are noninfective. Examples include indinavir sulfate, nelfinavir mesylate, ritonavir, and saquinavir.
HMG-CoA reductase i's a group of drugs that competitively inhibit the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, and are used to lower plasma lipoprotein levels in the treatment of hyperlipoproteinemia. Called also statins.
membrane inhibitor of reactive lysis (MIRL) protectin.
monoamine oxidase inhibitor any of a group of drugs that inhibit the action of monoamine oxidase, the enzyme that breaks down norepinephrine and serotonin, prescribed for their antidepressant action; the most widely used ones are isocarboxazid, phenelzine, and tranylcypromine. They are also used in the prevention of migraine.
α2-plasmin inhibitor α2-antiplasmin.
plasminogen activator inhibitor (PAI) any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator. Their concentration in plasma is normally low, but is altered in some disturbances of bodily hemostasis. PAI-1 is an important fast-reacting inhibitor of t-plasminogen activator and u-plasminogen activator. Its synthesis, activity, and release are highly regulated; elevated levels of it have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is protein C inhibitor.
platelet inhibitor any of a group of agents that inhibit the clotting activity of platelets; the most common ones are aspirin and dipyridamole. See also antiplatelet therapy.
protease inhibitor
1. a substance that blocks activity of endopeptidase (protease), such as in a virus.
protein C inhibitor the primary inhibitor of activated anticoagulant protein C; it is a glycoprotein of the serpin family of proteinase inhibitors and also inhibits several other proteins involved in coagulation (thrombin, kallikrein, and coagulation factors X and XI) and urokinase. Called also plasminogen activator inhibitor 3.
proton pump inhibitor gastric acid pump i.
reverse transcriptase inhibitor a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an antiretroviral agent. Some are nucleosides or nucleoside analogues, and those that are not are therefore often called non-nucleoside reverse transcriptase inhibitors.
selective serotonin reuptake inhibitor (SSRI) any of a group of drugs that inhibit the inactivation of serotonin by blocking its absorption in the central nervous system; used as antidepressants and in the treatment of obsessive-compulsive disorder and panic disorder.
serine protease inhibitor (serine proteinase inhibitor) serpin.
topoisomerase i's a class of antineoplastic agents that interfere with the arrangement of DNA in cells.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
References in periodicals archive ?
Moreover, the combination of foods containing tyramine and MAO inhibitors could potentially lead to hypertension (dos Santos 2013b; Frecska 2007; Yamada & Yasuhara 2004; Youdim & Weinstock 2004), although there is some controversy regarding the impact of this combination on the health of ayahuasca consumers.
Immunization of rats was attained using the MAO inhibitors isatin and deprenyl (N-dimetyl-N [2-propyl] benzenethanamine hydrochloride, ICN Biomedical Inc., USA), and fragments 30-33 (Trp-Met-AspPhe-N[H.sub.2]) and 31-33 (Met-Asp-Phe-N[H.sub.2] ICN Biomedical Inc., USA) of cholecystokinine covalently conjugated the antigen carrier bovine serum albumin (BSA).
Based on safety data presented by the manufacturer, "it is abundantly clear" that all three doses were safer in terms of the risk of hypertensive reactions than the MAO inhibitor tranylcypromine (Parnate), said Dr.
Bodkin pointed out that the way physicians think of MAO inhibitors could slow down prescribing of the patch.
There is evidence of clinically important drug-drug interactions between cannabis or cannabinoids and the following medications: chlorpromazine, clobazam, clozapine, CNS depressants (e.g., barbiturates, benzodiazepines), disulfiram, hexobarbital, hydrocortisone, ketoconazole, MAO inhibitors, phenytoin, protease inhibitors (indinavir, nelfinavir), theophylline, tricyclic antidepressants and warfarin.
Older medications for depression include tricyclics (Elavil, Pamelor) and MAO inhibitors (Nardil, Parnate), but these medications are rarely used, since the newer drugs are more effective and have fewer side effects for most patients.
The dichloromethane extract (0.001 to 100 [micro]g/mL), purified compounds ([10.sup.-9] to [10.sup.-2] M), and standard MAO inhibitors (phenelzine, clorgyline, and deprenyl) ([10.sup.-12] to [10.sup.-5] M) were tested on human MAOA and MAO-B enzymes [19].
Dopamine agonists 62.43% Levodopa 15.24% MAO inhibitors 11.75% COMT inhibitors 10.28% Anticholinergics 0.05% Amantadine 0.24% Note: Table made from pie chart.
Indeed, considering that various so-called MAO inhibitors can also interact with other AOs, we asked whether resveratrol, known to exert antioxidant activities, known to activate sirtuins [14, 15], and recently described to inhibit MAO [2, 16], was able to interact with SSAO, too.
Research on these natural substances manifests a need to find new and safe MAO inhibitors, and among such substances devoid of any serious side effects we can list Rhodiola rosea L.
It can also have interactions with various drug groups like SSRIs and MAO inhibitors to cause serotonin syndrome (2,3) and can present with tachycardia, hypertension, hyperthermia, agitation and even seizures, among other signs and symptoms.