MALT1


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MALT1

A gene on chromosome 18q21 that encodes a protein which enhances BCL10-induced activation of NF-kappaB and is involved in nuclear export of BCL10. MALT1 binds to TRAF6, inducing TRAF6 oligomerisation and activation of its ubiquitin ligase activity; MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.

Molecular pathology
MALT1 translocation t(11;18)(q21;q21) with BIRC2 occurs in ± 50% of cytogenetically abnormal low-grade MALT lymphomas.
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We are confident that these joint efforts will increase our understanding of MALT1 and its role in autoimmunity and oncology, with the aim of discovering and developing more effective patient treatments.
Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18.
BCL2, BCL6, MYC, MALT1, and BCL10 rearrangements in nodal diffuse large B-cell lymphomas: a multicenter evaluation of a new set of fluorescent in situ hybridization probes and correlation with clinical outcome.
23) Thirty-one cases evaluated for MALT1 by FISH were all negative; however, 14 of 31 cases (45%) displayed gains of the MALT1 signal consistent with +18q, and gains using a CEP3 probe consistent with +3 were found in 16 of 29 cases (55%).
MALT1 gene rearrangements and NF-kappaB activation involving p65 and p50 are absent or rare in primary MALT lymphomas of the breast.