MAGEB3

MAGEB3

A gene on chromosome Xp21.3 that encodes a MAGE family protein which directs expression of tumour antigens recognised on a human melanoma by autologous cytolytic T cells.
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The deletion involved the five following genes: MAGEB2, MAGEB3, MAGEB4, MAGEB1, and NR0B1 (DAX1).
The role of the MAGE genes (MAGEB1, MAGEB2, MAGEB3, and MAGEB4) is still unknown; however it is known that they are expressed in embryonic tissues, in some tumors, and after birth only in the testes [31].