atrogin-1

(redirected from MAFbx)

atrogin-1

An E3 ubiquitin ligase expressed in cardiac and skeletal muscle that directs muscle protein degradation after the muscle atrophy response has been triggered by Akt1-induced phosphorylation of FOXO, a transcription factor which also activates ubiquitin ligases and MuRF-1. Atrogin-deficient mice are resistant to muscle atrophy.
References in periodicals archive ?
Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle.
Blomstrand, "Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle," American Journal of Physiology-Endocrinology and Metabolism, vol.
Ja em relacao as vias de degradacao, destaca-se a via proteassomal, representada pelo sistema ubiquitina-proteassoma, que age de forma seletiva na proteolise muscular, atuando de forma importante no processo atrofico atraves da sinalizacao de duas ligases chave desse sistema, conhecidas como MURF-1 e MAFBx.
Two of these E3 ligases--atrogin-1 (also known as MAFbx) and MuRF1--are specific to the muscle.
The ubiquitin-proteasome degradation of muscle proteins in paretic limbs following the severe sensorimotor deficits after cerebral ischemia involves a biomolecular mechanism in muscle fibers that inhibits the Akt/mTOR pathway and increases, besides myostatin, many actors of the ubiquitin-proteasome degradation such as muscle RING finger-1 or MuRF1, muscle atrophy F-box (MAFbx), and muscle ubiquitin ligase of SCF complex in atrophy-1 or Musa1 [96].
As vias de sintese como a da mTOR ou de degradacao como MURF-1 e MAFbx estao constantemente sendo estudadas sobre a influencia de diversas condicoes para a potencializacao ou controle de sua expressao e nesse sentido tem sido considerada para estudos cientificos.
Curcumin prevents lipopolysaccharide-induced atrogin-1/ MAFbx upregulation and muscle mass loss.
Akt inhibits protein degradation by repressing the forkhead box protein (FoxO) family, leading to expression of atrogin-1/Muscle Atrophy F-box (MAFbx) and Muscle RING-Finger Protein-1 (MuRF1) (Brunet et al.
Indeed, independently of the etiology, muscle atrophies are commonly identified by the upregulation of the same set of genes, the so-called atrophy-related genes, or atrogenes, among which atrogin-1/muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MuRF1) are well documented.
To our surprise, TNF-[alpha]-induced effect was associated with both activation of Myhc IIa, Atroginl (also known as MAFbx), and MuRF1 genes, but proteolysis took over protein accretion.
Maak, "Evaluation of MAFbx expression as a marker for congenital splay leg in piglets," Developments in Biologicals, vol.