atrogin-1

(redirected from MAFbx)

atrogin-1

An E3 ubiquitin ligase expressed in cardiac and skeletal muscle that directs muscle protein degradation after the muscle atrophy response has been triggered by Akt1-induced phosphorylation of FOXO, a transcription factor which also activates ubiquitin ligases and MuRF-1. Atrogin-deficient mice are resistant to muscle atrophy.
References in periodicals archive ?
reported that TNF-[alpha] upregulates the expression of MuRF1 but not of MAFbx (Cai et al.
Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle.