Repeated resistance exercise training induces different changes in mRNA expression of MAFbx
and MuRF-1 in human skeletal muscle.
Blomstrand, "Repeated resistance exercise training induces different changes in mRNA expression of MAFbx
and MuRF-1 in human skeletal muscle," American Journal of Physiology-Endocrinology and Metabolism, vol.
Ja em relacao as vias de degradacao, destaca-se a via proteassomal, representada pelo sistema ubiquitina-proteassoma, que age de forma seletiva na proteolise muscular, atuando de forma importante no processo atrofico atraves da sinalizacao de duas ligases chave desse sistema, conhecidas como MURF-1 e MAFBx
Two of these E3 ligases--atrogin-1 (also known as MAFbx
) and MuRF1--are specific to the muscle.
The ubiquitin-proteasome degradation of muscle proteins in paretic limbs following the severe sensorimotor deficits after cerebral ischemia involves a biomolecular mechanism in muscle fibers that inhibits the Akt/mTOR pathway and increases, besides myostatin, many actors of the ubiquitin-proteasome degradation such as muscle RING finger-1 or MuRF1, muscle atrophy F-box (MAFbx
), and muscle ubiquitin ligase of SCF complex in atrophy-1 or Musa1 .
As vias de sintese como a da mTOR ou de degradacao como MURF-1 e MAFbx
estao constantemente sendo estudadas sobre a influencia de diversas condicoes para a potencializacao ou controle de sua expressao e nesse sentido tem sido considerada para estudos cientificos.
Curcumin prevents lipopolysaccharide-induced atrogin-1/ MAFbx
upregulation and muscle mass loss.
The expressions of the muscle-specific RING-finger protein 1 (MuRF1) and muscle atrophy F-box (MAFbx
) mRNA of denervated skeletal muscle have been reported in the literature (Moriscot et al., 2010; Goncalves et al., 2012).
Akt inhibits protein degradation by repressing the forkhead box protein (FoxO) family, leading to expression of atrogin-1/Muscle Atrophy F-box (MAFbx
) and Muscle RING-Finger Protein-1 (MuRF1) (Brunet et al.
Indeed, independently of the etiology, muscle atrophies are commonly identified by the upregulation of the same set of genes, the so-called atrophy-related genes, or atrogenes, among which atrogin-1/muscle atrophy F-box (MAFbx
) and muscle RING finger 1 (MuRF1) are well documented.
To our surprise, TNF-[alpha]-induced effect was associated with both activation of Myhc IIa, Atroginl (also known as MAFbx
), and MuRF1 genes, but proteolysis took over protein accretion.
Maak, "Evaluation of MAFbx
expression as a marker for congenital splay leg in piglets," Developments in Biologicals, vol.