SMAD2

(redirected from MADR2)

SMAD2

A gene on chromosome 18q21.1 that encodes a SMAD family protein, named for their similarity to the Drosophila gene Mothers Against Decapentaplegic (MAD), which are signal transducers and transcription modulators of multiple signalling pathways. SMAD2 mediates the signal of transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes—e.g., cell proliferation, apoptosis and differentiation. In response to the binding of TGF-beta, SMAD2 is phosphorylated and dissociated from the SMAD anchor for receptor activation (SARA) protein and forms a complex with SMAD4, resulting in transcription regulation.
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Por otra parte, existen otros genes supresores de tumores ubicados en la region cromosomica 18q21, que tambien son inactivados por perdidas alelicas, estos son: DPC4 (por la sigla en ingles de deleted in pancreatic cancer) y MADR2 (por la sigla en ingles de mothers against decapentaplegic relatedprotein-2) (41).