MADIT


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MADIT

Cardiology A clinical trial–Multicenter Automatic Defibrillator Implantation Trial that evaluated the effects of implanted defibrillators–IDs in Pts with CAD at high risk of ventricular arrhythmia
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A regression analysis on patients from the MADIT II (13) demonstrated a U-shaped curve for efficacy of ICD in primary prevention of SCD.
As a result of these landmark findings from MADIT and other studies, the American College of Cardiology, the North American Society of Pacing and Electrophysiology, and the American Heart Association issued joint guidelines calling for expanded use of ICDs for the primary prevention of sudden cardiac death.
The results of the MADIT II clinical trial, published earlier this year in the New England Journal of Medicine, demonstrated that placement of an ICD in patients with a prior myocardial infarction and a left ventricular ejection fraction of 30% or less resulted in a 5.
Not only can device therapy provide a reduction in the risk of sudden death--and that is what the MADIT II trial was all about--but it can also alleviate symptoms.
Previous trials, including MADIT, MUSTT and AVID, have demonstrated that implantable defibrillators improve survival in other patient populations.
Arthur Moss, lead investigator of the MADIT II trail, to learn more about the study and its potential in saving the lives of high-risk heart patients, like Joe Lepley and Vice President Dick Cheney.
Results from the MADIT II trial, involving more than 1,200 patients with impaired left ventricular function after MI, were released 2 years ago.
While many studies over the years have demonstrated the benefits of ICDs, the MADIT II trial of 1,232 patients convincingly showed the benefits of ICDs implanted in patients who had a prior heart attack and an ejection fraction of less than 30 percent.
This group of patients is outside of the MADIT II and SCDHeFT populations as the study included only patients with a left ventricular ejection fraction (LVEF) greater than or equal to 0.
For example, evidence from MADIT II (the second Multicenter Automatic Defibrillator Implantation Trial) elevated the recommendation--that implantable cardiac defibrillators (ICDs) be used for primary prevention of sudden cardiac arrest in patients who have ischemic cardiomyopathy due to prior MI, have a left ventricular ejection fraction of less than 30%, and are New York Heart Association functional class I--from a class IIa recommendation ("it is reasonable") to a class I recommendation (it "should be performed/administered").