NFKBIA

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NFKBIA

A gene on chromosome 14q132 that encodes an I-kappa-B protein that inhibits the multimeric NFKB complex by trapping it in the cytoplasm. Kinases IKBKA or IKBKB phosphorylate NFKBIA’s serine residues, marking them for destruction via the ubiquination pathway, allowing activation of the NFKB complex which, once activated, translocates to the nucleus, binds DNA and activates transcription.
References in periodicals archive ?
tU BADJ Tulisa's loving her new role as panellist Hip-HOppiNG MAD3 Fazer
Table 6 P-values from Pair-wise T-tests on Means of MAD's from MA(1), MA(3), MA(5), MA(7), MA (9) for the Normal Probability Distribution with c.v.= 1 k MAD1 MAD3 MAD5 MAD7 MAD9 3 MAD1 -- 0.000 0.000 0.000 0.000 MAD3 -- -- 0.000 0.000 0.000 MADS -- -- -- 0.000 0.000 MAD7 -- -- -- -- 0.000 5 MAD1 -- 0.000 0.000 0.000 0.000 MAD3 -- -- 0.000 0.000 0.000 MAD5 -- -- -- 0.000 0.000 MAD7 -- -- -- -- 0.000 7 MAD1 -- 0.000 0.000 0.000 0.000 MAD3 -- -- 0.000 0.000 0.000 MAD5 -- -- -- 0.000 0.000 MAD7 -- -- -- -- 0.000 9 MADI -- 0.000 0.000 0.000 0.000 MAD3 -- -- 0.000 0.000 0.000 MAD5 -- -- -- 0.000 0.000 MAD7 -- -- -- -- 0.000 Table 7 P-values from Pair-wise T-tests on Means of RMAPE's from MA(1), MA(3), MA(5), MA(7), MA(9) for the Normal Probability Distribution with c.v.
HIp-HOppING MAD3 Fazer TU BADJ Tulisa's loving her new role as panellist