MACF1

MACF1

A gene on chromosome 1p32-p31 that encodes F-actin-binding protein, which is thought to play a role in cross-linking actin to other cytoskeletal proteins and to microtubules. MACF1 plays a key role in ERBB2-dependent stabilisation of microtubules at the cell membrane, it upregulates the Wnt-receptor signalling pathway, and it is involved in translocating AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. It has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics.

MACF1 may deliver transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. It also plays a key role in wound healing and epidermal cell migration; it is required for efficient upward migration of bulge cells in response to tissue trauma, which reflects its ability to co-ordinate microtubule dynamics and polarise hair follicle stem cells.
Mentioned in ?
References in periodicals archive ?
A small number of cases with other BRAF fusion gene partners have also been found, including FAM131B, RNF130, CLCN6, MKRN1, GNA11, QKI, FXR1, and MACF1 (6,54).
Analysis of gene expression of cytoskeleton regulators indicated that short-term exposure of ASCs to 0.1% [O.sub.2] downregulated the expression of ACTR3, DSTN, MACF1, MIDI, MYPT1, NCK1, ROCK1, TIAM1, and WASF1, the products of which represent important regulators of [beta]-actin depolymerisation and lamellipodia formation.
The other components of the network (ACTR3, DSTN, MACF1, MID1, MYPT1, NKC1, TIAM1, and WASF1) are structural proteins or effectors, but are not key regulators of cell function, and their protein interactions are poorly understood.
MACF1 Protein as a novel target for the treatment of brain and lung cancer.
Because depth was important and we desired a panel no larger than 1 Mb, several large genes previously shown mutated i cancer but with no direct clinical implications were not included, such as titin (TTN), [15] Wolf-Hirschhorn syndrome candidate 1 (WGHSC1, also known as NSD2), and microtubule-actin crosslinking factor 1 (MACF1).