IGFBP7

(redirected from MAC25)

IGFBP7

A gene on chromosome 4q12 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family which that insulin-like growth factors I and II and circulates in the plasma. IGFBP7 stimulates prostacyclin production and cell adhesion.

Molecular pathology
A variant of IGFBP7 has been associated with retinal arterial macroaneurysm.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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Li et al., "Down-regulation of T1A12/ mac25, a novel insulin-like growth factor binding protein related gene, is associated with disease progression in breast carcinomas," Oncogene, vol.
One should also note that both of the studies cited determined DARC and mac25 as novel markers for high ECs.