In this study, we used VNTR and WGS to test the hypothesis that household plumbing is a reservoir for NTM and is responsible for some cases of pulmonary MAC infection
Ten of the evaluable patients have MAC infection
and four have MABSC infection.
His past medical history was significant for a diagnosis of a colonic MAC infection
found on colonic biopsy and a subsequent diagnosis of AIDS 3 months previously.
In both cases of MAC causing HLH, correct diagnosis was delayed highlighting the difficulty of promptly identifying MAC infection
with currently available diagnostic technology.
During the ART era, MAC infection
has developed into a completely new disease.
(1) While MAC is ubiquitous in the environment and is the most common disease-causing NTM in humans, there are very few reported cases of MAC infection
in the urine and only two reported cases of asymptomatic MAC urine infection.
showed that CA 19-9 was a marker for the deterioration of a MAC infection
in association with BMI and CRP.
The granulomas in MAC infection
are small ill-formed with proliferation of foamy macrophages.
Unmasking IRD comprised 4 patients with tuberculosis and 2 with MAC infection
The AIDS Clinical Trials Group 362 study, reported in abstract form at the recent Interscience Conference on Antimicrobial Agents and Chemotherapy showed no cases of disseminated MAC infection
in 643 HIV-positive patients randomized to a year of weekly azithromycin prophylaxis or placebo, according to Dr.
(3) Although the detection of MAC organisms in the respiratory or gastrointestinal tract may be predictive of the development of disseminated MAC infection
, no data are available on the efficacy of prophylaxis with clarithromycin, azithromycin, rifabutin, or other drugs in patients with MAC organisms at these sites and a negative blood culture.
Patients with skin/soft tissue infections were more commonly female (58%), whereas disseminated infections occurred predominantly in male patients (67%); of these, 79% of patients had MAC infection
. The median age of patients with disseminated infections was 41 years, and 60% of these infections occurred in HIV-positive patients.