MAC disease


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Mycobacterium avium complex disease

 
a systemic disease caused by infection with organisms of the Mycobacterium avium-intracellulare complex in patients with human immunodeficiency virus (HIV) infection. Signs and symptoms include bacteremia, fever, chills, fatigue, night sweats, weight loss, abdominal pain, anemia, and elevated alkaline phosphatase. Called also MAC disease
References in periodicals archive ?
With MAC disease, there is often a delay between acquisition of infection and diagnosis, during which time mutations will accumulate in the environmental reservoir and the clinical isolates.
Although it is widely believed that disseminated MAC disease results from reactivation of a latent infection, recent data suggest that the disease may develop from recent infection via the respiratory or gastrointestinal tract.[6]
(2) Adults and adolescents who have HIV infection should receive chemoprophylaxis against disseminated MAC disease if they have a CD4+ T-lymphocyte count of <50 cells/[mu]L (AI).
fortuitum pulmonary disease did not differ from survival with MAC disease. The worse crude survival observed with M.
Interactions between protease inhibitors and the rifamycins also have complicated prophylaxis and treatment for disseminated MAC disease. Rifabutin is one of the drugs recommended for MAC prophylaxis (16).
MAC is short for Mycobacterium avium complex, the germs that cause MAC disease. People get MAC disease when their immune systems are weakened.