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Abbreviation for monoclonal antibody.
Mabs are used in diagnostics by radioactively labelling them to target malignant cells, detect metastases and screen body fluids for microorganisms, or measure levels of circulating hormones.
Alternative healthcare providers may include therapeutic Mabs as a part of treatment.
A highly specific antibody formed by a clone of B lymphocytes, either naturally (e.g., in cold haemagglutinin) or produced synthetically by fusing an immortal cell (mouse myeloma) to a cell producing an antibody against a desired antigen.
Mabs are increasingly used in cancer management as they directly inhibit the growth of certain tumours, can be chemically bound to toxins that are lethal to malignant cells, stimulate the complement system in destroying malignant cells, can be used to purge the BM of malignant cells, and form the basis for vaccines and drug delivery systems.
Allergic reactions, fevers, chills, hypotension, liver and kidney problems.
Mabs are used in pathology to differentiate tumour subtypes with batteries of Mabs raised against intermediate filaments or membrane antigens.