In fact, bringing to light the precise whereabouts of the tag - a genetic switch called m6A
- and understanding how it operates is of crucial importance because its role, which has been shadowy until recently, is key for regulating the genome.
In January 2018, Gotham and ZoBio initiated a collaboration to develop small-molecule inhibitors of the "writer" protein complex METTL3/METTL14, a SAM-dependent methyltransferase that modifies mRNA encoded adenosine in the messenger RNA to m6A
and thereby regulates protein expression.
Citation: Jasmin Paris et al., Targeting the RNA m6A
Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.
is one of the markers in mRNA methylation, and modifications take place in nascent prem-RNAs predominantly .
In the present review article, we highlight advances in another base modification N6-methyladenine which exists in both DNA (m6dA) and RNA (m6A
) and is not new in terms of its discovery history, but its biological functions are being gradually unveiled only in recent years in regulation of the development and stem cell fate.
Specifically, they studied N6-methyladenosine (m6A
) and N6, 2-O-dimethyladenosine modifications to messenger RNAs.
Not long ago, the overexpression of M6a
was reported not only to induce both neurites formation and increase in filopodium/spine density in primary cultures of rat hippocampus  but also to be involved in synaptogenesis .
Flugge, "Expression of the axonal membrane glycoprotein M6a
is regulated by chronic stress," PLoS ONE, vol.
Recent studies suggested that m6A
is a key molecule and its modification by FTO creates a code for the regulation of gene expression and in turn protein translation [2, 13].
They found widespread changes in a recently identified epigenetic mark, N6-methyladenosine (m6A
), on RNA when new memories were formed.