EPCAM

(redirected from M4S1)

EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
phureja Mediante RT-qPCR y RT-PCR convencional Muestra Municipio de RT-qPCR para CP RT-PCR procedencia Valor de Q Valor CP CPm Ct (b) de Tm (c) C- >35 - - c+ La Union 18,32 77,52 + + MISI Entrerrios >35 - - M1S2 Entrerrios >35 - - M1S3 Entrerrios >35 - - M2S1 Marinilla 26,01 77,28 - - M2S2 Marinilla 24,58 77,30 - - M2S3 Marinilla 27,03 77,30 - - M3S1 Marinilla 29,34 77,37 - - M3S2 Marinilla 26,19 77,48 - - M3S3 Marinilla >35 - - M4S1 El Penol >35 - - M4S2 El Penol >35 - - M4S3 El Penol >35 - - Sintl Entrerrios 16,55 77,82 + + Sint2 Marinilla 19,73 77,46 + + Sint3 Marinilla 22,45 77,55 + + Sint4 El Penol 17,19 77,50 + + (a) C- y C+: control negativo y positivo; M: se refiere a muestras asintomaticas; Sint: muestras con sintomas de amarillamiento de venas.