(51,69) Unlike AML M4Eo
, where granules are enlarged, the granules in chronic eosinophilic leukemia associated with FIP1L1-PDGFRA are commonly small and sparse (Figure 2, A and B).
(73.) Schnittger S, Bacher U, Haterlach C, Kern W and Haferlach T, Rare CBFB-MYH11 fusion transcripts in AML with inv(16)/t(16;16) are associated with therapy-related AML M4eo
, atypical cytomorphology, atypical immunophenotype, atypical additional chromosomal rearrangements and low white blood cell count: a study on 162 patients Leukemia 2007;21:725-31.
Two patients had AL (one type B, common; and one biphenotypic), and 105 had acute myeloid leukemia: 1 with French-American-British subtype Mo, 11 with subtype M1, 13 with subtype M2, 65 with subtype M3, 4 with subtype M4, 2 with subtype M4Eo
, 5 with subtype M5, 2 with subtype M6, 1 who was not classified, and 1 with subtype M1 at relapse.
Patients with t(8; 21) frequently present with the French-American-British (FAB) morphologic subtype M2 or acute myeloid leukemia with differentiation, while patients with inv(16) more often are diagnosed with FAB subtype M4Eo
or acute myelomonocytic leukemia with eosinophilia.
Detection of inv(16) and t(16;16) by fluorescence in situ hybridization in acute myeloid leukemia M4Eo
. Haematologica 2000;85:481-5.
Clinical aspects of acute myeloid leukemias of the Fab types M3 and M4Eo
. AML Cooperative Group.