His primary research interests are the molecular epidemiology of M. tuberculosis
and the genetics of its pathogenicity.
doesn't immediately cause illness in most people.
Particularly alarming is the increase in the number of people with multidrug-resistant TB (MDR-TB), caused by M. tuberculosis
strains resistant to two or more drugs.
While the normal function of macrophages is to engulf and kill microorganisms, M. tuberculosis
relies on as-yet-unknown ways to evade destruction and persist in these cells.
This report is the first known of epidemiologically associated TB in human and canine cases to be confirmed by M. tuberculosis
The TIGR project should be complete in a month, but it will not duplicate the effort of Cole's group, which sequenced a strain of M. tuberculosis
studied since 1905.
What could explain the way the Yanomami respond to M. tuberculosis
? De Sousa, an immunologist by trade, decided to look more closely at the immune system of the Yanomami.
When persons become infected with M. tuberculosis
, one of the following can occur: 1) they can progress quickly to disease (with probability p); 2) they can become latently infected with M.
From an evolutionary point of view, the multiple rpoB mutations in M. tuberculosis
have been hypothesized to arise as a compensatory mechanism to ameliorate the fitness costs of the original resistance mutation by a secondary mutation (11).
A team of researchers in Europe has recently discovered that M. tuberculosis
does not actively acquire resistance to isoniazid - as many other types of bacteria acquire resistance to various antibiotics - but instead loses its susceptibility to isoniazid.
RFLP analysis using the IS6110 insertion sequence represents the standard criterion for differentiating M. tuberculosis
', but it is insufficiently discriminating for M bovis due to the paucity of 1S6110 elements in the genome of this bacterium.
We report on the pattern of drug resistance to first-line anti-TB drugs among M. tuberculosis
complex isolates from Zone 1 TB center in Yangon, which receives approximately 70% of the national TB programs' TB cases in Yangon.