PLA2R1

(redirected from M-type receptor)

PLA2R1

A gene on chromosome 2q23-q24 that encodes a C-type lectin domain protein which acts as a receptor for secretory phospholipase sPLA2-IB, but not for sPLA2-IIA. Binding of sPLA2-IB/PLA2G1B induces different effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells, and activation of p38 MAPK to stimulate elastase release and cell adhesion in neutrophils.

References in periodicals archive ?

Boilard et al., "Recombinant production and properties of binding of the full set of mouse secreted phospholipases [A.sub.2] to the mouse M-type receptor," Biochemistry, vol.

Mammalian N-type receptors have been identified for sPL[A.sub.2]IB and IIA, X and M-type receptors for sPL[A.sub.2]IB, IIA, IIE, IIF, V, and X [72].

By interacting with heparan sulphate proteoglycans and M-type receptors, they can induce PG[D.sub.2] and LT[C.sub.4] production and stimulate the subsequent degranulation of mast cells [75].

The involvement of phospholipases [A.sub.2] in asthma and chronic obstructive pulmonary disease

Due to the variety of muscarinic receptors taking part in signal transduction and activation of stomach smooth muscles it seemed reasonable to examine firstly general participation of M-type receptors in [alpha]-hederin-induced contraction of isolated stomach strips followed by the contribution of particular M-type receptors.

Participation of cholinergic pathways in [alpha]-hederin-induced contraction of rat isolated stomach strips