PLA2R1

(redirected from M-type receptor)

PLA2R1

A gene on chromosome 2q23-q24 that encodes a C-type lectin domain protein which acts as a receptor for secretory phospholipase sPLA2-IB, but not for sPLA2-IIA. Binding of sPLA2-IB/PLA2G1B induces different effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells, and activation of p38 MAPK to stimulate elastase release and cell adhesion in neutrophils.
References in periodicals archive ?
Boilard et al., "Recombinant production and properties of binding of the full set of mouse secreted phospholipases [A.sub.2] to the mouse M-type receptor," Biochemistry, vol.
Mammalian N-type receptors have been identified for sPL[A.sub.2]IB and IIA, X and M-type receptors for sPL[A.sub.2]IB, IIA, IIE, IIF, V, and X [72].
By interacting with heparan sulphate proteoglycans and M-type receptors, they can induce PG[D.sub.2] and LT[C.sub.4] production and stimulate the subsequent degranulation of mast cells [75].
Due to the variety of muscarinic receptors taking part in signal transduction and activation of stomach smooth muscles it seemed reasonable to examine firstly general participation of M-type receptors in [alpha]-hederin-induced contraction of isolated stomach strips followed by the contribution of particular M-type receptors.