One patient achieved a minimal response with a 48% reduction in their m-protein
. The other patient achieving a minimal response had a 39% reduction in m-protein
remains on study and continues to be evaluated.
AMGUS stands for monoclonal gammopathy of undetermined significance, and it means that your husband's blood sample contained an abnormal protein (monocolonal or M-protein
(IgG-e type) was found by routine examination of serum protein electrophoresis, which revealed an increase in a globulin, accounting for 28.6% (reference value, 9.2-18.2%).
The first sign of myeloma for the patient in this study, a 57-year-old woman, was an incidental finding of M-protein
(18 g/L) during a consult for hypertension in 2007.
spike of 15 g/L or more on the SPE; the presence of non-IgG MGUS; and an abnormal serum free light-chain ratio of less than 0.26 or more than 1.65.
The vast majority of participants reported using a perpendicular-drop approach to M-protein
quantitation, and a smaller percentage use tangent skimming (Table 1, question C).
MGUS is denoted by less than 3 g/dl M-protein
concentration in serum, no or only small amounts of Bence Jones protein in the urine, less than 10% plasma cells in the bone marrow, together with no evidence of lytic bone lesions, anemia, high calcium levels and renal impairment.3
The masses of the light-chain peaks from the IgG-enriched preparation and from the [kappa]-enriched preparation were identical, indicating the presence of an IgG [kappa] M-protein
. Similarly, the masses of the IgA peak and of the [lambda] peak were identical, indicating the presence of an IgA [lambda] M-protein
MM (and other M-protein
secretory conditions from MGUS to Waldenstrom's macroglobulinemia) can cause polyneuropathy on their own right.
Serum immunoelectrophoresis showed monoclonal M-protein
In some patients, instead of the signs typically observed in MG (such as lytic bone lesions, hypercalcemia, anemia, and renal insufficiency), the most revealing symptoms are those of a dysfunctional endocrine system, thus confounding the diagnosis of MG--an especially likely situation when the presence of monoclonal protein (M-protein
) is very weak and the serum protein electrophoresis (sPEP) profile appears normal.
Serum immunoelectrophoresis showed an increase in M-protein
[immunoglobulin (IgG) [kappa] type] and also a decrease in albumin of plasma and albumin/globulin ratio was lower than normal.