M-protein

myomesin-2

A 165-kD protein encoded by MYOM2 on chromosome 8p23.3, which is involved in maintaining sarcomeric architecture, and located at the central myofibrillar M band of muscle, binding myosin, titin, and light meromyosin, and is critical for muscle contraction.

M-protein

Monoclonal or myeloma protein; paraprotein; abnormal antibody found in large amounts in the blood and urine of individuals with multiple myeloma.
Mentioned in: Multiple Myeloma
References in periodicals archive ?
The M-protein is a surrogate marker of the PC clone, and as such, the diagnosis and management of PCDs depends on accurate identification, characterization, and quantification of M-proteins.
In contrast to the common isotype of MM where the serum M-protein is usually >30g/L of IgG and >20g/L of IgA (3), our patient serum M-protein quantification was of 2.
hyaluronic acid capsule as an immunological disguise and to inhibit phagocytosis; M-protein to inhibit phagocytosis
1] Diagnostic criteria for EMP include a tissue biopsy showing monoclonal plasma cell activity, absence of evidence of multiple myeloma, a low or absent M-protein concentration and absence of hypercalcaemia or renal failure.
The M-protein is a major virulence factor for GAS and 80 variations of this protein have been identified to date, through sequencing of the emm gene.
Immunoelectrophoresis revealed M-protein composed with a kappa chain.
An M-protein and/or light chain in the serum and/or urine is found in 97% of the patients.
In principle, the effectiveness of this type of M-protein vaccine may be highly dependent on how well the M proteins selected for the vaccine match the emm types of locally circulating strains.
The T cells respond to antigenic short peptides common to streptococcal M-protein and skin keratins, Dr.
Thompson, 2002) During this presymptomatic period a small number of clonal plasma cells produce low levels of M-protein, known as 'monoclonal gammopathy of undetermined significance' (MGUS) (Kumar et al, 2009) The risk of progression to multiple myeloma is very small--approx 1% per year, but patients may be more susceptible to bacterial infections, particularly pneumonia.
Is psoriasis induced by streptococcal superantigens and maintained by M-protein specific T cells that cross react with keratin.
3) These include the presence of (1) clonal bone marrow plasma cells or plasmacytoma, (2) an M-protein in serum of unspecified concentration, and (3) tissue- or organ-related impairment, such as renal insufficiency or anemia.