is a surrogate marker of the PC clone, and as such, the diagnosis and management of PCDs depends on accurate identification, characterization, and quantification of M-proteins
In contrast to the common isotype of MM where the serum M-protein
is usually >30g/L of IgG and >20g/L of IgA (3), our patient serum M-protein
quantification was of 2.
hyaluronic acid capsule as an immunological disguise and to inhibit phagocytosis; M-protein
to inhibit phagocytosis
1] Diagnostic criteria for EMP include a tissue biopsy showing monoclonal plasma cell activity, absence of evidence of multiple myeloma, a low or absent M-protein
concentration and absence of hypercalcaemia or renal failure.
is a major virulence factor for GAS and 80 variations of this protein have been identified to date, through sequencing of the emm gene.
Immunoelectrophoresis revealed M-protein
composed with a kappa chain.
and/or light chain in the serum and/or urine is found in 97% of the patients.
In principle, the effectiveness of this type of M-protein
vaccine may be highly dependent on how well the M proteins selected for the vaccine match the emm types of locally circulating strains.
The T cells respond to antigenic short peptides common to streptococcal M-protein
and skin keratins, Dr.
Thompson, 2002) During this presymptomatic period a small number of clonal plasma cells produce low levels of M-protein
, known as 'monoclonal gammopathy of undetermined significance' (MGUS) (Kumar et al, 2009) The risk of progression to multiple myeloma is very small--approx 1% per year, but patients may be more susceptible to bacterial infections, particularly pneumonia.
Is psoriasis induced by streptococcal superantigens and maintained by M-protein
specific T cells that cross react with keratin.
3) These include the presence of (1) clonal bone marrow plasma cells or plasmacytoma, (2) an M-protein
in serum of unspecified concentration, and (3) tissue- or organ-related impairment, such as renal insufficiency or anemia.