amsacrine(redirected from M-AMSA)
Also found in: Acronyms.
amsacrineA topoisomerase inhibitor with antineoplastic activity; it can also intercalate into the DNA of tumour cells, altering major and minor grooves therein, thereby inhibiting DNA replication and transcription by reducing association between the altered DNA and DNA polymerase, RNA polymerase and transcription factors.
Acute lymphoblastic leukaemia, lymphoma.
Bone marrow suppression.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
amsacrineA cytotoxic drug used to treat acute myeloid leukaemia. A brand name is Amsidine.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005