M-tropic strain

M-tropic strain

A strain of HIV-1 that infects macrophages and activated T cells, the entry of which is facilitated by CCR5 (a co-receptor for chemokines), RANTES, and MIP 1 alpha and MIP 1 beta; binding of these chemokines to CCR5 blocks the entry of M-tropic strains.

Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

M-tropic strain

AIDS A strain of HIV-1 that infects macrophages and activated T cells, the entry of which is facilitated by CCR5, a coreceptor for chemokines, RANTES, MIP 1α, MIP 1β; binding of these chemokines to CCR5 blocks the entry of M strains. Cf T-tropin strain.

McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.