In addition, the standard PCR is incapable of distinguishing between latent and lytic infection
. Although extensive development for PCR assays has been made, the lack of standardization of the laboratory and quality assurance procedures persist to be constant challenges.
Therefore, felines coinfected with FcaGHV1 and FIV may present a lytic infection
by gammaherpesvirus, allowing the detection viral DNA at this stage (BEATTY et al., 2014).
Wang et al., "Epstein-Barr virus lytic infection
is required for efficient production of the angiogenesis factor vascular endothelial growth factor in lymphoblastoid cell lines," Journal of Virology, vol.
refers to the situation in which the virus replicates in a host cell and causes its lysis, releasing hundreds to thousands of progeny virions.
Of the genes tested, IFN-[beta] and IFN-[gamma] were upregulated in the CT of both infected lines during lytic infection
. The expression levels of both genes were much higher in the susceptible line than in the resistant line.
(14,22) RNAi has also been reported to inhibit HSV-1 replication by using siRNAs targeting glycoprotein E that plays key role in cell-to-cell spread and virus-induced cell fusion (20); DNA polymerase gene and VP16 play vital roles in initiation of viral gene expression and viral proliferation (22) and ICP4 is a major regulatory gene required for efficient transcription of early and late viral genes making it essential for lytic infection
. (19) These studies that applied RNAi to interfere HSV-1 infection suggested that these small sequences might have the potential for effective therapeutic alternative in patients with HSV-1 infection.
After the first lytic infection
, EBV persists in resting memory B-cells for the rest of the patient's life and can switch between an active lytic cycle and a latent state from which it occasionally reactivates, making it a continuous challenge to the patient's immune system .
Initial subclinical infection probably occurs in childhood; however, in severe immunosuppression, reactivation of the virus leads to a lytic infection
of oligodendrocytes in the brain.
demonstrated the possibility of a temperature-dependent reactivation of CyHV-3 lytic infection
several months after initial exposure to the virus (32) .
Probably such effects will be of limited significance within the context of an active, productive and lytic infection
, where the host cell has no long-term future.