Lysyl oxidase | definition of lysyl oxidase by Medical dictionary
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ly·syl ox·i·dase [MIM*153455]
an enzyme, which requires Cu2+ and O2, that oxidizes certain lysyl residues in collagen to allysyl residues and hydroxylysyl residues to hydroxyallysyl residues; this is a required step for the cross-linking (via aldol condensations and through Amadori rearrangements) of collagen strands; a lower activity of this enzyme is associated with occipital horn syndrome.
An enzyme required for the crosslinking of elastin and collagen molecules to form properly functioning connective tissue; present in relatively low levels in at least some forms of cutis laxa.
a copper-containing enzyme responsible for the maintenance of collagen and elastin in tissues; its absence leads to aneurysm formation in and rupture of large blood vessels.
References in periodicals archive
Increased lysyl oxidase activity in blood vessels of hypertensive rats and effect of betaaminopropionitrile on arteriosclerosis.
Lysyl oxidases in mammalian development and certain pathological conditions.
Hypoxia-induced lysyl oxidase
is a critical mediator of bone marrow cell recruitment to form the premetastatic niche.
Second are similarities of post-translational pathways, such as lysyl oxidase
But the defective gene does not code for lysyl oxidase
Copper, lysyl oxidase
, and extracellular matrix protein cross-linking.
While studying breast cancer in mice, Janine's team have found that in the absence of the LOX enzyme, full name lysyl oxidase
, new environments in the body would be too hostile for the cancer to grow.
The lysyl oxidases lysyl oxidase
(LOX) and (LOXL) are responsible for elastin cross-linking.
, which catalyzes the posttranslational modification essential to the pathogenesis of connective tissue matrices, is irreversibly inactivated by homocysteine thiolactone (10).